29096-75-1

Basic information

• Product Name: 2-Amino-5,6-dimethylbenzimidazole
• Synonyms: 1H-Benzimidazol-2-amine, 5,6-dimethyl-;LABOTEST-BB LT00080715;2-AMINO-5,6-DIMETHYLBENZIMIDAZOLE;5,6-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE;5,6-dimethylbenzimidazol-2-ylamine;1H-Benzimidazol-2-amine,5,6-dimethyl-(9CI);5,6-DIMETHYL-1H-BENZO[D]IMIDAZOL-2-AMINE;2-amino-5,6-dimethylimidazole
• CAS NO: 29096-75-1
• Molecular Formula: C9H11N3
• Molecular Weight: 161.2
• EINECS: 249-430-2
• Product Categories: BENZIMIDAZOLE;pharmacetical;A;Stains and Dyes;Stains&Dyes, A to
• Mol File: 29096-75-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 220-223 °C (dec.)(lit.)
• Boiling Point: 389.3 °C at 760 mmHg
• Flash Point: 217.7 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 2.87E-06mmHg at 25°C
• Refractive Index: 1.705
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.47±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5,6-dimethylbenzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5,6-dimethylbenzimidazole(29096-75-1)
• EPA Substance Registry System: 2-Amino-5,6-dimethylbenzimidazole(29096-75-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 29096-75-1(Hazardous Substances Data)

Usage

General Description

2-Amino-5,6-dimethylbenzimidazole is a chemical compound that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. It is an organic molecule with a unique structure that contains both an amino group and a benzimidazole ring, giving it potential for drug development and therapeutic applications. 2-Amino-5,6-dimethylbenzimidazole has been studied for its potential to act as an antineoplastic and antiviral agent, and it has also been investigated for its anti-inflammatory and antimicrobial properties. Additionally, 2-Amino-5,6-dimethylbenzimidazole has shown potential in the treatment of various diseases, making it a valuable chemical in the field of pharmaceutical research and development.

InChI:InChI=1/C9H11N3/c1-5-3-7-8(4-6(5)2)12-9(10)11-7/h3-4H,1-2H3,(H3,10,11,12)

Upstream product

• 506-68-3 bromocyane 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 6972-71-0 4,5-dimethyl-2-nitrobenzenamine 

Downstream Products

• 105958-35-8 C₃₂H₂₆N₃⁽¹⁺⁾*BF₄^(1-) 
• 109929-41-1 7,8-Dimethyl-2,4-diphenyl-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 123199-80-4 N-(5,6-dimethylbenzimidazol-2-yl)salicylamide 
• 60882-73-7 5,6-dimethyl-1,2-diaminobenzimidazole 
• 15777-04-5 1-ethyl-5,6-dimethyl-1H-benzoimidazol-2-ylamine 
• 141472-57-3 [5,6-Dimethyl-1-(3-methyl-benzyl)-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 141472-58-4 [5,6-Dimethyl-1-(2-methyl-benzyl)-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 141472-56-2 [5,6-Dimethyl-1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 141472-68-6 [1-(2-Chloro-benzyl)-5,6-dimethyl-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 141472-60-8 [1-(3-Fluoro-benzyl)-5,6-dimethyl-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 141472-67-5 [1-(3-Chloro-benzyl)-5,6-dimethyl-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 141472-59-5 [1-(3-Methoxy-benzyl)-5,6-dimethyl-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 141472-66-4 [1-(4-Chloro-benzyl)-5,6-dimethyl-1H-benzoimidazol-2-yl]-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amine 
• 1228507-42-3 N-(5,6-dimethyl-1H-benzimidazol-2-yl)-3,5-bis(trifluoromethyl)benzamide 

Relevant articles and documents

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.

Cu-Catalyzed Synthesis of 3-Formyl Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrimidines by Employing Ethyl Tertiary Amines as Carbon Sources

A highly efficient synthesis of 3-formyl imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine, under Cu-catalyzed aerobic oxidative conditions and by utilizing ethyl tertiary amines as carbon sources, is disclosed. A novel activation mode of ethyl tertiary amines in which simultaneous selective cleavage of C-C bond and C-N bond of ethyl group with molecular oxygen as terminal oxidant in this one-pot protocol is reported for the first time. This reaction features broad substrate scope, good functional group tolerance, as well as diversified and valuable products.

2-aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms

Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known. Copyright