122292-24-4

Upstream product

• 112452-63-8 Acetic acid (E)-(1R,2R,3R,4S)-3-acetoxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,4,7-trimethyl-oct-5-enyl ester 
• 115115-21-4 3(R)-<1(S),4-dimethyl-2-(E)-pentenyl>-4(R)-methyl-5-(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-dihydro-2(3H)-furanone 
• 122292-23-3 1-<(tert-butyldiphenylsilyl)oxy>-2(R),4(R),6(S),9-tetramethyldec-7(E)-ene-3(R),5(R)-diol 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 122213-37-0 (2R,6R)-6-{(4S,5S,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-methyl-5-oxo-heptanal 
• 122213-36-9 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane 
• 122213-44-9 8(R)-<(tert-butoxycarbonyl)methyl>-2(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-3(R),5(R),9(R)-trimethyl-(6R)-1,7-dioxaspiro<5.5>undecane 
• 122213-39-2 hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane 
• 122213-38-1 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(R)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane 
• 122213-41-6 [(2R,3R,6R)-6-((R)-1-{(4S,5S,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-6-methoxy-3-methyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester 
• 122213-34-7 (E)-(2S,6R)-4-Benzenesulfonyl-2-{(4R,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-ol 
• 122213-35-8 (E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one 
• 122213-43-8 {(2R,3R,6S,8R,9S,10S,11R)-8-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3,9,11-trimethyl-10-phenoxythiocarbonyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid tert-butyl ester 
• 122213-29-0 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<1(R)-methyl-2-formylethyl>-2,2,5(S)-trimethyl-1,3-dioxane 
• 122213-42-7 4(S)-hydroxy-8(R)-<(tert-butoxycarbonyl)methyl>-2(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-3(R),5(R),9(R)-trimethyl-(6R)-1,7-dioxaspiro<5.5>undecane 
• 122213-42-7 4(S)-hydroxy-8(S)-<(tert-butoxycarbonyl)methyl>-2(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-3(R),5(R),9(R)-trimethyl-(6S)-1,7-dioxaspiro<5.5>undecane 
• 122292-25-5 (S)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol 

Relevant academic research and scientific papers

Formal Synthesis of (-)-Calcimycin (A-23187) via the 3-Methyl-γ-butyrolactone Approach

A synthesis of (+)-carboxylic acid 2a, which has been previously converted into the ionophore (-)-calcimycin (A-23187) and analogues thereof, is described.The synthesis involves the use of (S)-3-methyl-γ-butyrolactone (4) and both enantiomers of allylic alcohol 3a as the chiral entities.