122292-23-3Relevant academic research and scientific papers
Formal Synthesis of (-)-Calcimycin (A-23187) via the 3-Methyl-γ-butyrolactone Approach
Ziegler, Frederick E.,Cain, William T.
, p. 3347 - 3353 (2007/10/02)
A synthesis of (+)-carboxylic acid 2a, which has been previously converted into the ionophore (-)-calcimycin (A-23187) and analogues thereof, is described.The synthesis involves the use of (S)-3-methyl-γ-butyrolactone (4) and both enantiomers of allylic alcohol 3a as the chiral entities.
3-METHYL-γ-BUTYROLACTONE AS A SOURCE OF 2-METHYL-3-HYDROXYKETONES AND 2-METHYL-1,3-DIOLS: A SYNTHESIS OF THE C19-C27 FRAGMENT OF RIFAMYCIN S BY LINEAR ITERATION
Ziegler, Frederick E.,Kneisley, Alyssa
, p. 1725 - 1728 (2007/10/02)
3-Methyl-γ-butyrolactone has been employed as a source of 2-methyl-3-hydroxyketones after functioning as a template for the preparation of enantiomerically pure propionate chains.This method is exemplified by the preparation of the C19-C27 propionate frag
