122296-00-8

Basic information

• Product Name: 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE&
• Synonyms: 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE 99%;benzotriazol-1-ylmethyl(trimethyl)silane
• CAS NO: 122296-00-8
• Molecular Formula: C₁₀H₁₅N₃Si
• Molecular Weight: 205.33
• Product Categories: C-C Bond Formation;Others;Synthetic Reagents
• Mol File: 122296-00-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 56-60 °C(lit.)
• Boiling Point: 300.3°C at 760 mmHg
• Flash Point: 135.4°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.00202mmHg at 25°C
• Refractive Index: 1.556
• Solubility: Well soluble in most organic solvents.
• CAS DataBase Reference: 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE&(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE&(122296-00-8)
• EPA Substance Registry System: 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE&(122296-00-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 122296-00-8(Hazardous Substances Data)

Usage

Physical properties

mp 55–56 °C.

Uses

Different sources of media describe the Uses of 122296-00-8 differently. You can refer to the following data:
1. 1-[(Trimethylsilyl)methyl]- 1H-benzotriazole is a reagent in the preparation of ketones, carboxylic acids,One-carbon Homologation of Carboxylic Acids,Synthesis of Fused Heterocycles and fused heterocycles.
2. New Benzotriazole ReagentsReactant for:Alkylation reactionsPreparation of inhibitor of p53-MDM2 complex formationUsed as a one-carbon synthon for one-carbon homologation of carboxylic acids

Preparation

1-[(trimethylsilyl)methyl]-1H-benzotriazole is readily prepared in a reaction of sodium benzotriazolide with chloromethyltrimethylsilane.

InChI:InChI=1/C10H15N3Si/c1-14(2,3)8-13-10-7-5-4-6-9(10)11-12-13/h4-7H,8H2,1-3H3

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 2344-80-1 Chloromethyltrimethylsilane 
• 158530-85-9 trimethylsilanylmethyltrifluoromethane sulphonate 
• 15217-42-2 sodium benzotriazolate 

Downstream Products

• 174182-62-8 2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-methoxyphenyl)ethan-1-one 
• 361379-11-5 1-(1H-1,2,3-benzotriazol-1-yl)-4-phenyl-2-butanone 
• 361379-09-1 2-(1H-1,2,3-benzotriazol-1-yl)-1-(3-methylphenyl)-1-ethanone 
• 1393669-64-1 2-(1H-benzotriazol-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone 
• 1393669-59-4 2-(1H-benzotriazol-1-yl)-1-(4-fluorophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 163729-25-7 2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethanone 
• 122296-03-1 1-<2-phenyl-1,1-bis(trimethylsilyl)ethyl>benzotriazole 
• 300396-51-4 1-[2-(4-methylphenyl)-1-ethenyl]-1H-1,2,3-benzotriazole 
• 19155-24-9 3,3-dimethyloxindole 

Relevant articles and documents

Synthesis and structure of 1- and 2-isomers of (trimethoxysilylmethyl)- and (silatranylmethyl)benzotriazole

We have synthesized 1- and 2-(trimethylsilylmethyl)- and 1- and 2-(trimethoxysilylmethyl)benzotriazoles by reaction of 1,2,3- benzotriazolylsodium with trimethyl- or trimethoxy(chloromethyl)silane. We obtained 1- and 2-(silatranylmethyl)benzotriazoles by

Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues

In order to get a clearer view on the active geometry of anti-invasive chalcones, we have prepared a number of isoxazoles and related substances as conformationally restrained mimics of 1,3-diarylpropenones, and also of (Z)-stilbenes. In vitro anti-invasi

Benzotriazoles. Part 15. The preparation of 1-(1-alkenyl)benzotriazoles

The title compounds are prepared either (A) from 1-(1-chloroalkyl)benzotriazoles and aldehydes via Wittig reaction or (B) from 1-benzotriazoles by alkylative desilylation by fluoride ion in the presence of a carbonyl compound