1222981-70-5Relevant academic research and scientific papers
First total synthesis and structural confirmation of fluvirucinine A 2 via an iterative ring expansion strategy
Lee, Yong-Sil,Jung, Jong-Wha,Kim, Seok-Ho,Jung, Jae-Kyung,Paek, Seung-Mann,Kim, Nam-Jung,Chang, Dong-Jo,Lee, Jeeyeon,Suh, Young-Ger
, p. 2040 - 2043 (2010)
Figure presented The first asymmetric total synthesis of fluvirucinine A2 has been accomplished. A key feature of the synthesis is an iterative lactam ring expansion to provide rapid access to the 14-membered lactam skeleton and three stereogenic centers. The excellent remote control of the three stereogenic centers relied on stereoselective amidoalkylation followed by an amide-enolate-induced aza-Claisen rearrangement. In addition, the structure of fluvirucinine A2 has been completely elucidated by our total synthesis.
