1223091-48-2Relevant academic research and scientific papers
Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes
Begum, Zubeda,Sannabe, Haruka,Seki, Chigusa,Okuyama, Yuko,Kwon, Eunsang,Uwai, Koji,Tokiwa, Michio,Tokiwa, Suguru,Takeshita, Mitsuhiro,Nakano, Hiroto
, p. 203 - 209 (2020)
Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature.
Sugar based γ-amino alcohol organocatalyst for asymmetric Michael addition of β-keto esters with nitroolefins
Begum, Zubeda,Chennapuram, Madhu,Ganesan, Divakar,Kwon, Eunsang,Nakano, Hiroto,Okuyama, Yuko,Seki, Chigusa,Takeshita, Mitsuhiro,Tokiwa, Michio,Tokiwa, Suguru,Uwai, Koji
, p. 1536 - 1545 (2020/01/28)
Sugar based γ-amino alcohol was used in asymmetric Michael addition of β-keto esters with nitroolefins for the first time affording the corresponding several chiral Michael adducts bearing quaternary chiral carbon center in moderate to good chemical yields and stereoselectivities (up to 98%, up to dr. 95:5, up to 84% ee).
Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction
Lattanzi, Alessandra,De Fusco, Claudia,Russo, Alessio,Poater, Albert,Cavallo, Luigi
supporting information; experimental part, p. 1650 - 1652 (2012/03/11)
A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a me
Catalytic asymmetric 1,4-additions of β-keto esters to nitroalkenes promoted by a bifunctional homobimetallic Co2-schiff base complex
Furutachi, Makoto,Chen, Zhihua,Matsunaga, Shigeki,Shibasaki, Masakatsu
experimental part, p. 532 - 544 (2010/05/02)
Catalytic asymmetric 1,4-addition of β-keto esters to nitroalkenes is described. 2.5 mol % of a homobimetallic Lewis acid/Bronsted base bifunctional Co2-Schiff base complex smoothly promoted the reaction in excellent yield (up to 99%), diastereoselectivity, and enantioselectivity (up to >30:1 dr and 98% ee). Catalyst loading was successfully reduced to 0.1 mol %. Mechanistic studies suggested that intramolecular cooperative functions of the two Co-metal centers are important for high catalytic activity and stereoselectivity.
