122320-81-4

Basic information

• Product Name: Ethanol, 2-(methyl-2-thiazolylamino)-
• Synonyms: Ethanol, 2-(methyl-2-thiazolylamino)-
• CAS NO: 122320-81-4
• Molecular Formula: C₆H₁₀N₂OS
• Molecular Weight: 0
• Mol File: 122320-81-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanol, 2-(methyl-2-thiazolylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-(methyl-2-thiazolylamino)-(122320-81-4)
• EPA Substance Registry System: Ethanol, 2-(methyl-2-thiazolylamino)-(122320-81-4)

Safety Data

• Hazardous Substances Data: 122320-81-4(Hazardous Substances Data)

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 3034-52-4 2-chlorothiazole 

Downstream Products

• 122320-88-1 4-[2-(N-Methyl-N-(2-thiazolyl)amino)ethoxy]benzaldehyde 
• 1111238-48-2 C₁₈H₂₃N₃O₆S 
• 122320-78-9 4-[2-(N-Methyl-N-(2-pyrimidinyl)amino)ethoxy]-benzaldehyde 
• 100374-38-7 4-amino-2-hydroxy-benzoic acid-[2-(methyl-thiazol-2-yl-amino)-ethyl ester] 

Relevant articles and documents

Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression

Anti-inflammatory effects of peroxisome proliferator-activated receptor gamma (PPRAγ) ligands are thought to be largely due to PPARγ-mediated transrepression. Thus, transrepression-selective PPARγ ligands without agonistic activity or with only partial agonistic activity should exhibit anti-inflammatory properties with reduced side effects. Here, we investigated the structure-activity relationships (SARs) of PPARγ agonist rosiglitazone, focusing on transrepression activity. Alkenic analogs showed slightly more potent transrepression with reduced efficacy of transactivating agonistic activity. Removal of the alkyl group on the nitrogen atom improved selectivity for transrepression over transactivation. Among the synthesized compounds, 3l exhibited stronger transrepressional activity (IC50: 14?μM) and weaker agonistic efficacy (11%) than rosiglitazone or pioglitazone.

Compounds

Compounds of formula (I): STR1 or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; R2 and R3 each represent hydrogen, or R2 and R3 together represent a bond; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6; pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine.

COMPOUNDS

Compounds of formula (I) or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; R2 and R3 each represent hydrogen, or R2 and R3 together represent a bond; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6; pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine