122324-18-9Relevant academic research and scientific papers
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease
Marco-Contelles, José,León, Rafael,De Los Ríos, Cristóbal,Guglietta, Antonio,Terencio, José,Lòpez, Manuela G.,Garcìa, Antonio G.,Villarroya, Mercedes
, p. 7607 - 7610 (2006)
In this work we describe the synthesis and biological evaluation of the tacrine-1,4-dihydropyridine (DHP) hybrids (3-11). These multipotent molecules are the result of the juxtaposition of an acetylcholinesterase inhibitor (AChEI) such as tacrine (1) and
Organic base grafted on magnetic nanoparticles as a recoverable catalyst for the green synthesis of hydropyridine rings
Bodaghifard, Mohammad Ali
, p. 483 - 492 (2019/11/03)
Synthesis of 4-aminiquinaldine grafted on silica-coated nano-Fe3O4 particles (MNPs-AQ) and their performance as a retrievable heterogeneous basic catalyst are disclosed. The catalytic performance of this novel material was studied fo
Bis(4-pyridylamino)triazine-stabilized magnetite nanoparticles: preparation, characterization and application as a retrievable catalyst for the green synthesis of 4H-pyran, 4H-thiopyran and 1,4-dihydropyridine derivatives
Bodaghifard,Mobinikhaledi,Asadbegi
, (2017/02/05)
Synthesis of bis(4-pyridylamino)triazine stabilized on silica-coated nano-Fe3O4 particles, and their feasibility as a reusable heterogeneous basic catalyst are reported. The catalytic performance of this novel material was studied fo
CuI nanoparticles as new, efficient and reusable catalyst for the one-pot synthesis of 1,4-dihydropyridines
Safaei-Ghomi, Javad,Ziarati, Abolfazl,Teymuri, Raheleh
, p. 2679 - 2682 (2012/10/29)
A simple one-pot synthesis of two derivatives of 1,4-dihydropyridines has been described under reflux conditions using copper iodide nanoparticles (CuI NPs) as a catalyst in high yields. This method demonstrated four-component coupling reactions of aldehy
Synthesis of 1,4-dihydropyridine derivatives under solvent-free and grinding conditions
Zonouz, Adeleh Moshtaghi,Moghani, Davoud
, p. 2152 - 2160 (2011/07/07)
An efficient and environmentally friendly synthesis of 6-amino-5-cyano-1,4- dihydropyridine derivatives was developed by the one-pot reaction of ethyl acetoacetate, [(2-aryl)methylene]malononitriles, and ammonium acetate at room temperature with grinding.
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease
Marco-Contelles, José,León, Rafael,De Los Ríos, Cristóbal,Samadi, Abdelouahid,Bartolini, Manuela,Andrisano, Vincenza,Huertas, Oscar,Barril, Xavier,Luque, F. Javier,Rodríguez-Franco, María I.,López, Beatriz,López, Manuela G.,García, Antonio G.,Carreiras, María Do Carmo,Villarroya, Mercedes
supporting information; experimental part, p. 2724 - 2732 (2010/02/28)
Tacripyrines (1-14) have been designed by combining an AChE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. Tacripyrines are selective and potent AChE inhibito
