1223403-86-8

Upstream product

• 1223403-85-7 (R)-methyl 1-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-ylcarbamoyl)cyclopropanecarboxylate 
• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 1223404-88-3 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine 

Relevant academic research and scientific papers

Substituted pyrazolo [1,5-a] pyrimidine compound used as Trk kinase inhibitor

The invention relates to a substituted pyrazolo [1,5-a] pyrimidine compound used as a Trk kinase inhibitor, or pharmacologically acceptable salt, a medicine composition and a purpose. A pyrazolo [1,5-a] pyrimidine derivative in the structure with a genera

SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS

Compounds of Formula (I) in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.