154257-75-7

Basic information

• Product Name: 3-Chloro-2,4-difluorobenzoic acid
• Synonyms: 3-Chloro-2,4-difluorobenzoic acid 97%;3-Chloro-2,4-difluorobenzoicacid97%;3-CHLORO-2,4-DIFLUOROBENZOIC ACID;2,4-Difluoro-3-Chlorobenzoic Acid
• CAS NO: 154257-75-7
• Molecular Formula: C₇H₃ClF₂O₂
• Molecular Weight: 192.55
• EINECS: 216-280-4
• Product Categories: Benzoic acid
• Mol File: 154257-75-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 174-176°C
• Boiling Point: 276.707 °C at 760 mmHg
• Flash Point: 121.149 °C
• Appearance: /
• Density: 1.574 g/cm³
• Vapor Pressure: 0.00228mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.84±0.10(Predicted)
• BRN: 7290655
• CAS DataBase Reference: 3-Chloro-2,4-difluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2,4-difluorobenzoic acid(154257-75-7)
• EPA Substance Registry System: 3-Chloro-2,4-difluorobenzoic acid(154257-75-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 26-36-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 154257-75-7(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

Uses

2,4-Difluoro-3-chlorobenzoic Acid is a useful synthetic intermediate. It can be used to prepare fungicidal arylpyrazoles or quinolinones as antimicrobials.

InChI:InChI=1/C7H3ClF2O2/c8-5-4(9)2-1-3(6(5)10)7(11)12/h1-2H,(H,11,12)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 36556-37-3 1,3-dichloro-2,4-difluorobenzene 
• 201849-13-0 3-Chloro-2,4-difluoro-bromobenzene 
• 20485-44-3 2,3-dimethyl-2,3-diaminobutane 
• 67-72-1 hexachloroethane 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 887267-38-1 3-chloro-2,4-difluorobenzonitrile 
• 81067-37-0 1-bromo-2,3,4-trichlorobenzene 
• 87-61-6 1,2,3-trichlorobenzene 
• 1435-44-5 1-chloro-2,4-difluorobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 38361-37-4 1-chloro-2,6-difluorobenzene 

Downstream Products

• 157373-00-7 3-chloro-2,4-difluoro-benzoyl chloride 
• 1000162-62-8 C₇H₂ClF₂IO₂ 
• 163656-30-2 2,4-difluoro-3,5-dichlorobenzoic acid 
• 1223446-46-5 methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate 
• 1223445-62-2 methyl 5-acetyl-3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoate 
• 1223444-87-8 methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoate 
• 1223444-78-7 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoic acid 
• 860296-14-6 3-chloro-4-fluoro-2-hydroxybenzoic acid 

Relevant articles and documents

Synthesis method of 3-chloro-2,4-difluorobenzoic acid

The invention relates to a synthesis method of 3-chloro-2,4-difluorobenzoic acid. The method comprises: taking 1,2,3-trichlorobenzene and N-bromosuccinimide to react, taking CuCN and 1-bromo-2,3,4-trichlorobenzene to react, taking the 1-bromo-2,3,4-trichlorobenzene and KF to react and taking 3-chloro-2,4-difluorobenzonitrile and sulfuric acid to react, so as to form the 3-chloro-2,4-difluorobenzoic acid. According to the synthesis method, synthesis reaction conditions are that a reaction is carried out at normal pressure and reaction temperature fluctuates between 0 and 250 DEG C; the obtained finished product is a light yellow powdery solid and the content is more than or equal to 99.0 percent; the total mol yield of the 3-chloro-2,4-difluorobenzoic acid can reach 61.5 percent; whole reaction conditions are moderate and the method is convenient to operate and control; pressure of waste gas, waste water and waste residues is relatively low so that industrial production is facilitated.

ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES

Compounds of the following formula (I) are effective antimicrobial agents.

Antimicrobial quinolones, their compositions and uses

Compounds having the general structure: which are effective antimicrobial agents.