154257-75-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2,4-difluorobenzoic acid is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its chemical structure allows for the development of new drugs with potential applications in treating different health conditions.
Used in Agricultural Industry:
In the agricultural sector, 3-Chloro-2,4-difluorobenzoic acid is utilized as a key component in the synthesis of fungicidal arylpyrazoles and quinolinones. These antimicrobial compounds are effective in controlling fungal infections in crops, thereby improving agricultural productivity and crop protection.
Used in Chemical Synthesis:
3-Chloro-2,4-difluorobenzoic acid serves as an essential building block in the synthesis of various organic compounds. Its unique chemical properties make it a valuable precursor for the development of new materials and chemicals with diverse applications in different industries.

InChI:InChI=1/C7H3ClF2O2/c8-5-4(9)2-1-3(6(5)10)7(11)12/h1-2H,(H,11,12)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 36556-37-3 1,3-dichloro-2,4-difluorobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 201849-13-0 3-Chloro-2,4-difluoro-bromobenzene 
• 20485-44-3 2,3-dimethyl-2,3-diaminobutane 
• 67-72-1 hexachloroethane 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 887267-38-1 3-chloro-2,4-difluorobenzonitrile 
• 81067-37-0 1-bromo-2,3,4-trichlorobenzene 
• 87-61-6 1,2,3-trichlorobenzene 
• 1435-44-5 1-chloro-2,4-difluorobenzene 
• 38361-37-4 1-chloro-2,6-difluorobenzene 

Downstream Products

• 157373-00-7 3-chloro-2,4-difluoro-benzoyl chloride 
• 1354962-79-0 tert-butyl 3-chloro-2,4-difluorobenzoate 
• 1354962-78-9 3-chloro-4-(4-chloro-3-(trifluoromethyl)phenoxy)-2-fluorobenzoic acid 
• 163656-30-2 2,4-difluoro-3,5-dichlorobenzoic acid 
• 1223446-46-5 methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate 
• 1223445-62-2 methyl 5-acetyl-3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoate 
• 1223444-87-8 methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoate 
• 1223444-78-7 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoic acid 
• 860296-14-6 3-chloro-4-fluoro-2-hydroxybenzoic acid 

Relevant academic research and scientific papers

Synthesis method of 3-chloro-2,4-difluorobenzoic acid

The invention relates to a synthesis method of 3-chloro-2,4-difluorobenzoic acid. The method comprises: taking 1,2,3-trichlorobenzene and N-bromosuccinimide to react, taking CuCN and 1-bromo-2,3,4-trichlorobenzene to react, taking the 1-bromo-2,3,4-trichlorobenzene and KF to react and taking 3-chloro-2,4-difluorobenzonitrile and sulfuric acid to react, so as to form the 3-chloro-2,4-difluorobenzoic acid. According to the synthesis method, synthesis reaction conditions are that a reaction is carried out at normal pressure and reaction temperature fluctuates between 0 and 250 DEG C; the obtained finished product is a light yellow powdery solid and the content is more than or equal to 99.0 percent; the total mol yield of the 3-chloro-2,4-difluorobenzoic acid can reach 61.5 percent; whole reaction conditions are moderate and the method is convenient to operate and control; pressure of waste gas, waste water and waste residues is relatively low so that industrial production is facilitated.

Promoting or preventing haloaryllithium isomerizations: Differential basicities and solvent effects as the crucial variables

Deprotonation-triggered heavy halogen migrations should become a favorite tool in arene synthesis if their occurrence and outcome could be made predictable. Particularly attractive, though extremely rare, are stop-and-go situations where a first intermediate, generated by metalation, can be trapped at -100 °C, whereas at -75 °C halogen migration gives rise to an isomer. As shown now, one can conveniently produce the initial aryllithium species by halogen/metal interconversion in toluene at -100 °C, under conditions that preclude, halogen migration, and unleash the isomerization process by adding tetrahydrofuran at -75 °C.

ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES

Compounds of the following formula (I) are effective antimicrobial agents.

Process for making certain benzoic acid compounds

The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then treating

Antimicrobial quinolones, their compositions and uses

Compounds having the general structure: which are effective antimicrobial agents.

Antimicrobial quinolones, their compositions and uses

Compounds having the general structure: which are effective antimicrobial agents.

Antimicrobial quinolones, their compositions and uses

This invention relates to novel antimicrobial compounds of formula; wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides and imides thereof, and to compositions and uses of such compounds. The invention also relates to compounds derived from these compounds having antimicrobial uses.

Fungicidal arylpyrazoles

The present invention relates to new derivatives of the family of 3-arylpyrazoles of formula (I), their methods of preparation, the compositions containing them and their utilization for the protection of plants against fungal diseases. STR1

Lithiations directed by carboxylic acid, fluorine and chlorine: The regioselective synthesis of polysubstituted benzoic acids and acetophenones

Lithiation/electrophilic quenching of ortho-lithiated benzoates allows the totally regiocontrolled synthesis of a wide range of 2,3-, 2,3,4-, and 2,3,4,5-polysubstituted benzoic acids and related acetophenones. Elsevier,.

Directed lithiation of unprotected benzoic acids

Benzoic acid gives the ortho-lithiated species 1 under standard conditions (s-BuLi-TMEDA-THF, -90 deg C).Reaction of 1 at -78 deg C with either methyl iodide, dimethyl disulfide, hexachloroethane, or 1,2-dibromotetrachloroethane gives the ortho-substituted product.Intramolecular competition between the carboxylic acid and methoxy, chloro, fluoro, or diethylamido functions in ortho- and -para-substituted benzoic acids establishes the carboxylic acid group to be of intermediate capacity in directing metallation.Complimentarity of directing effects is observed with the chloro and fluoro groups in the meta-substituted benzoic acid but not with the methoxy and trifluoromethyl groups.Electrophile introduction into meta- and para-lithiated benzoates occurs with equal efficacy and comparable scope.The 2,4-dihalogenobenzoic acids undergo hydrogen/metal exchange at the position flanked by both halogen substituents. 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid undergoes lithiation adjacent to the oxygen atom.By use of such methods, routes to benzoic acids contiguously tri- and tetra-substituted with a variety of functionalities have been developed.