1223452-56-9

Basic information

• Product Name: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone
• Synonyms: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone
• CAS NO: 1223452-56-9
• Molecular Weight: 269.26
• Mol File: 1223452-56-9.mol

Chemical Properties

• CAS DataBase Reference: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone(1223452-56-9)
• EPA Substance Registry System: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone(1223452-56-9)

Safety Data

• Hazardous Substances Data: 1223452-56-9(Hazardous Substances Data)

Upstream product

• 31930-18-4 2-amino-4-nitrobenzamide 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Preparation method of dihydroquinazolinone derivative

The invention discloses a preparation method of a dihydroquinazolinone derivative. The preparation method comprises the following steps: (1) respectively adding reaction substrate raw materials including aromatic aldehyde and 2-aminobenzamide and a proper amount of water into a pressure-resistant reaction container, (2) heating to 100-180 DEG C in a closed state, and keeping for a certain time, (3) stopping heating, cooling the reaction kettle to room temperature to 80 DEG C, and adding an organic solvent to flush the material into a collecting tank, (4) carrying out solid-liquid separation, washing and recrystallization to obtain the target product xanthene compound, and (5) collecting the solvent mother liquor and recovering the product, wherein the recovered solvent is reused. Comparedwith the prior art, the preparation method has the advantages of low cost and environmental protection.

High acidity cellulose sulfuric acid from sulfur trioxide: A highly efficient catalyst for the one step synthesis of xanthene and dihydroquinazolinone derivatives

A cellulose sulfonate catalyst (HS-cellulose sulfonate) with high stability, excellent catalytic activity and high acidity value (about 1.55 mmol g-1) was successfully prepared by SO3 gas phase sulfonation. The basic morphology and nanostructure of the catalyst were determined by HRTEM, XRD, IR, TG, etc. In addition, the catalyst was applied to the catalytic reaction of a dihydroquinazolinone derivative and a xanthene compound, and very valuable results were obtained. The development and preparation of cellulose sulfonate catalysts provide a good approach for the development and application of cellulose, and also an important application of green organic catalytic synthesis methodology.

Copper-catalyzed direct amination of ortho-functionalized haloarenes with sodium azide as the amino source

A simple copper-catalyzed direct amination of ortho-functionalized haloarenes (2-halobenzoic acid, 2-halobenzamide, and N-(2-bromophenyl)acetamide derivatives) has been developed with use of NaN3 as the amino source in ethanol, and the corresponding ortho-functionalized aromatic amines were synthesized in good to excellent yields. The protocol undergoes one-pot Ullmann-type coupling of ortho-functionalized haloarenes with NaN3 to lead to ortho-functionalized azidoarenes, followed by reduction with ethanol.