1223452-56-9

Basic information

• Product Name: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone
• Synonyms: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone
• CAS NO: 1223452-56-9
• Molecular Weight: 269.26
• Mol File: 1223452-56-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone(1223452-56-9)
• EPA Substance Registry System: 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone(1223452-56-9)

Safety Data

• Hazardous Substances Data: 1223452-56-9(Hazardous Substances Data)

Upstream product

• 31930-18-4 2-amino-4-nitrobenzamide 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Preparation method of dihydroquinazolinone derivative

The invention discloses a preparation method of a dihydroquinazolinone derivative. The preparation method comprises the following steps: (1) respectively adding reaction substrate raw materials including aromatic aldehyde and 2-aminobenzamide and a proper amount of water into a pressure-resistant reaction container, (2) heating to 100-180 DEG C in a closed state, and keeping for a certain time, (3) stopping heating, cooling the reaction kettle to room temperature to 80 DEG C, and adding an organic solvent to flush the material into a collecting tank, (4) carrying out solid-liquid separation, washing and recrystallization to obtain the target product xanthene compound, and (5) collecting the solvent mother liquor and recovering the product, wherein the recovered solvent is reused. Comparedwith the prior art, the preparation method has the advantages of low cost and environmental protection.

Copper-catalyzed direct amination of ortho-functionalized haloarenes with sodium azide as the amino source

A simple copper-catalyzed direct amination of ortho-functionalized haloarenes (2-halobenzoic acid, 2-halobenzamide, and N-(2-bromophenyl)acetamide derivatives) has been developed with use of NaN3 as the amino source in ethanol, and the corresponding ortho-functionalized aromatic amines were synthesized in good to excellent yields. The protocol undergoes one-pot Ullmann-type coupling of ortho-functionalized haloarenes with NaN3 to lead to ortho-functionalized azidoarenes, followed by reduction with ethanol.