1223461-33-3Relevant academic research and scientific papers
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
Chen, Austin,Bayly, Christopher,Bezen?on, Olivier,Richard-Bildstein, Sylvia,Dubé, Daniel,Dubé, Laurence,Gagné, Sébastien,Gallant, Michel,Gaudreault, Mireille,Grimm, Erich,Houle, Robert,Lacombe, Patrick,Laliberté, Sébastien,Lévesque, Jean-Fran?ois,Liu, Suzanna,MacDonald, Dwight,Mackay, Bruce,Martin, David,McKay, Dan,Powell, David,Remeň, L'ubo?,Soisson, Stephen,Toulmond, Sylvie
, p. 2204 - 2209 (2010)
The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. This work has led to the preparation of compounds with in vitro and in vivo profiles suitable for further development. Specifically, challenges p
