Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension

Article abstract of DOI:10.1016/j.bmcl.2010.02.036

The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. This work has led to the preparation of compounds with in vitro and in vivo profiles suitable for further development. Specifically, challenges p