Bioorganic and Medicinal Chemistry Letters p. 2204 - 2209 (2010)
Update date:2022-07-29
Topics:
Chen, Austin
Bayly, Christopher
Bezen?on, Olivier
Richard-Bildstein, Sylvia
Dubé, Daniel
Dubé, Laurence
Gagné, Sébastien
Gallant, Michel
Gaudreault, Mireille
Grimm, Erich
Houle, Robert
Lacombe, Patrick
Laliberté, Sébastien
Lévesque, Jean-Fran?ois
Liu, Suzanna
MacDonald, Dwight
Mackay, Bruce
Martin, David
McKay, Dan
Powell, David
Remeň, L'ubo?
Soisson, Stephen
Toulmond, Sylvie
The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. This work has led to the preparation of compounds with in vitro and in vivo profiles suitable for further development. Specifically, challenges p
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