122351-76-2Relevant academic research and scientific papers
Rigid Scaffolds: Synthesis of 2,6-Bridged Piperazines with Functional Groups in all three Bridges
Gao, Donglin,Penno, Christian,Wünsch, Bernhard
, p. 874 - 889 (2020)
The activity of pharmacologically active compounds can be increased by presenting a drug in a defined conformation, which fits exactly into the binding pocket of its target. Herein, the piperazine scaffold was conformationally restricted by substituted C
Synthesis and special structure of a novel low-generation amide dendrimer with pseudo-symmetric branch distribution
Meng, Qi,Chen, Juan-Juan,Li, Zheng-Yi,Li, Dan-Feng,Wu, Gui-Yong,Sun, Xiao-Qiang
experimental part, p. 432 - 434 (2011/01/12)
A novel low-generation amide dendrimer bearing four ester groups as terminal branches was conveniently synthesised by three-step reactions including acylation, hydrolysis and condensation from benzoyl chloride. Crystal X-ray diffraction and NMR analysis confirmed that one ester group of the four branches with pseudosymmetry was shielded by a benzene ring while the others were much further away. This was a difference from conventional dendrimers with symmetric branch distribution.
