122352-22-1

Usage

Uses

Used in Pharmaceutical Development:
[4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Scientific Research:
In the field of scientific research, [4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester serves as a valuable compound for studying the properties and reactivity of thiazole derivatives. It can be utilized in the exploration of new chemical reactions and the synthesis of novel heterocyclic compounds.
Used in Drug Delivery Systems:
Similar to other pharmaceutical compounds, [4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester can be employed in the development of innovative drug delivery systems. These systems aim to improve the bioavailability, targeting, and overall efficacy of drugs that incorporate [4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester.
Used in Chemical Synthesis:
[4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester can be used as a building block in the chemical synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science industries.

Upstream product

• 55453-49-1 ethyl 4-(ω-bromoacetyl)phenylacetate 
• 17356-08-0 thiourea 

Downstream Products

• 19749-93-0 2-chloroacetamido-4-thiazolyl acetic acid ethyl ester 
• 122352-21-0 (4-{2-Acetylamino-5-[2-acetylamino-4-(4-ethoxycarbonylmethyl-phenyl)-thiazol-5-ylsulfanyl]-thiazol-4-yl}-phenyl)-acetic acid ethyl ester 
• 122352-16-3 (4-{2-Amino-5-[2-amino-4-(4-ethoxycarbonylmethyl-phenyl)-thiazol-5-ylsulfanyl]-thiazol-4-yl}-phenyl)-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE)

Presently available medications for treatment of organiphosphorus poisoning are not sufficiently effective due to various pharmacological and toxicological reasons. In this regard, herein we report the synthesis of a series of N-thiazolylacetamide monoquaternary pyridinium oximes and its analogs (1a-1b to 6a-6b) with diversely substituted thiazole ring and evaluation of their in vitro reactivation efficacies against nerve agent (sarin, O-ethylsarin and VX) inhibited human erythrocyte acetylcholinesterase (hAChE). Reactivation kinetics was performed to determine dissociation constant (KD), reactivity rate constant (kr) and the second order rate constant (kr2) for all the compounds and compared their efficacies with commercial antidotes viz. 2-PAM and obidoxime. All the newly synthesized oximes were evaluated for their physicochemical parameters (pKa) and correlated with their respective reactivation efficacies to assess the capability of the oxime reactivator. Three of these novel compounds showed promising reactivation efficacies toward OP inhibited hAChE. Molecular docking studies were performed in order to correlate the reactivation efficacies with their interactions in the active site of the AChE.