55453-49-1

Upstream product

• 1528-42-3 ethyl 4-acetylphenylacetate 

Downstream Products

• 81950-45-0 [4-(7-Fluoro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-38-1 [4-(7-Chloro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-39-2 [4-(7-Methoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-40-5 [4-(7-Ethoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 87812-22-4 {4-[2-(4-Chloro-phenylamino)-acetyl]-phenyl}-acetic acid ethyl ester 
• 87812-23-5 {4-[2-(4-Fluoro-phenylamino)-acetyl]-phenyl}-acetic acid ethyl ester 
• 87812-24-6 {4-[2-(4-Bromo-phenylamino)-acetyl]-phenyl}-acetic acid ethyl ester 
• 122352-22-1 [4-(2-Amino-thiazol-4-yl)-phenyl]-acetic acid ethyl ester 
• 63363-00-8 ethyl [4-(α-phenoxy)acetyl] phenylacetate 

Relevant academic research and scientific papers

FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS

The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V): (I) [INSERTCHEMICAL STRUCTURE HERE] (V)[INSERT CHEMICAL STRUCTURE HERE] or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, R4, R6, R11, X1, X2, and X3 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also provides compounds within the scope of Formula I and relates to pharmaceutical compositions comprising these compounds.

Synthesis and Anthiinflammatory Activity of Some Arylimidazothiazolyl- and Arylimidazobenzothiazolyl-acetic Acids

Three series of the title compounds, imidazothiazolyl-, imidazobenzothiazolyl- and imidazobenzothiazolylaryl-acetic acids (II,III and IV) have been synthesised for evaluation as potential anti-inflammatory agents.Compounds II have been synthesised by condensing ethyl (2-amino-4-aryl-5-thiazolyl)acetate (VI) with phenacyl bromides followed by hydrolysis of the resultant esters (VII).III are obtained by the condensatiion of ethyl 2-aminobenzothiazole-6-acetate with phenacyl bromides followed by hydrolysis of the resultant esters (IX).Compound IV result from the treatment of 2-aminobenzothiazoles with ethyl 4(ω-bromoacetylphenyl)acetate (XI) followed by hydrolysis of the esters (XII).Some of the title compounds show good antiinflammatory activity.

Antimicrobial (2-nitro-3-benzofuranyl)phenylacetic acids

Optionally substituted (2-nitro-3-benzofuranyl)phenylacetic acids which are active as antimicrobial agents, processes for their preparation and intermediates therefor are described.