1223563-65-2

Upstream product

• 935560-23-9 2-amino-3-[6-(tert-butoxycarbonylamino-methyl)-2,2-diethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yloxy]-3-[6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-propionic acid tert-butyl ester 

Downstream Products

• 1223563-51-6 5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-6-deoxy-6-(4-octylphenylureido)-1-(uracil-1-yl)-β-D-glycero-L-talo-heptofuranuronic acid trifluoroacetate salt 

Relevant academic research and scientific papers

Function-oriented synthesis of simplified caprazamycins: Discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria

The rational simplification of the caprazamycin (CPZ) class of nucleoside natural products was carried out to address their molecular complexity. First, analogues 6-8, where the diazepanone ring of the CPZ was removed and a lipophilic side chain was attached to either the C-7′ or N 6′ atom, were used to investigate the conformation-activity relationship. On the basis of this relationship, we designed the oxazolidine-containing uridine derivatives 18-21 by restricting the conformation of 6-8. As a result, the tBu ester derivatives 20 were found to be the most active against a range of bacterial strains containing VRE with a potency similar to that of the parent CPZs. This study provides a novel strategy for the development of a new type of antibacterial agent effective against drug-resistant bacteria.