122376-71-0

Upstream product

• 109-09-1 2-chloropyridine 
• 658-99-1 (3,4-difluorophenyl)acetonitrile 

Downstream Products

• 114667-00-4 3-(3,4-Difluoro-phenyl)-3-pyridin-2-yl-propylamine 
• 122376-87-8 2-(3,4-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile 

Relevant academic research and scientific papers

Method for treating conditions related to the glutamate receptor using carboxylic acid amide derivatives

The present invention is concerned with the use of carbonylamino derivatives of the formula wherein R signifies lower alkyl, lower alkenyl, lower alkinyl, cycloalkyl, lower alkoxy or CF3; R1signifies hydrogen or lower alkyl; R2and R3signify, independently from each other, hydrogen, halogen or nitro; Y signifies CH or N; n is 0-6; m is 0-2; as well as with their pharmaceutically acceptable salts for the treatment of diseases, which relate to metabotropic glutamate receptor antagonists and/or agonists.

Synthesis of Primary ω-Phenyl-ω-pyridylalkylamines

Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.