122408-69-9Relevant academic research and scientific papers
Potassium-Zincate-Catalyzed Benzylic C?H Bond Addition of Diarylmethanes to Styrenes
Liu, Yu-Feng,Zhai, Dan-Dan,Zhang, Xiang-Yu,Guan, Bing-Tao
, p. 8245 - 8249 (2018)
Direct functionalization of the benzylic C?H bond of diarylmethanes is an important strategy for the synthesis of diarylmethine-containing compounds. However, the methods developed to date for this purpose require a stoichiometric amount (usually more) of either a strong base or an oxidant. Reported here is the first catalytic benzylic C?H bond addition of diarylmethanes to styrenes and conjugated dienes. A potassium zincate complex, generated from potassium benzyl and zinc amide, acts as a catalyst and displays good activity and chemoselectivity. Considering the atom economy of the reaction and the ready availability of the catalyst, this reaction constitutes a practical, efficient method for diarylalkane synthesis.
