1224101-16-9Relevant academic research and scientific papers
Tricyclic-isoxazolidine analogues via intramolecular 1,3-dipolar cycloaddition reactions of nitrones
Saubern, Simon,Macdonald, James M.,Ryan, John H.,Woodgate, Ruth C.J.,Louie, Theola S.,Fuchter, Matthew J.,White, Jonathan M.,Holmes, Andrew B.
, p. 2761 - 2767 (2010)
The tricyclic-isoxazolidine analogues tetrahydrothiochromenoisoxazoles, hexahydroisoxazolequinolines and tetrahydroisoxazolepyranopyridines were prepared by an intramolecular 1,3-dipolar cycloaddition reaction of a nitrone with an alkene. For N-alkylated hexahydroisoxazolequinolines, reduction of the reaction time from two days to 40 min was achieved using microwave heating. The cyclization to form tetrahydroisoxazolepyranopyridines only proceeded when the alkene was substituted with an electron withdrawing group.
