1224375-07-8Relevant academic research and scientific papers
Synthesis, biological and medicinal significance of S-glycosido-thieno[2,3-d]-pyrimidines as new anti-inflammatory and analgesic agents
Hafez, Hend N.,El-Gazzar, Abdel-Rahman B.A.,Nawwar, Galal A.M.
, p. 1485 - 1493 (2010)
Several 2-thioglycosides were prepared. Glycosylation of 2-thioxo-thieno[2,3-d]-pyrimidines 5a,b with 1-bromo-2,3,5-tri-O-acetyl-α-d-arabinofuranosyle 7, 2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl and galacto-pyranosyl bromide 8a,b gave the protected β-d-nuclosides 10a,b and 13a-d in high yields, which were transformed to deacetylated derivatives 14a,b and 15a-d. The structures of the compounds were elucidated by spectral and elemental analysis. Anti-inflammatory and Analgesic activities screening of the new compounds (at a dose of 100?mg/kg body weight) utilizing in vivo acute carrageenan-induced paw oedema standard method exhibited that the deacetylated derivatives 14a,b and 15a-d possess highly promising activities.
