1224407-97-9Relevant academic research and scientific papers
Synthesis and preliminary evaluation of difluorinated 1,3-propanediones as potential agents in the treatment of breast cancer
Pathan, Tabreskhan,Ingale, Sachin,Sharma, Ashish,Mohan, Rhea,Ramaa
, p. 584 - 589 (2012/08/07)
A series of difluorinated propanediones were synthesized and evaluated for in vitro cytotoxic activity by Sulforhodamine B (SRB) assay against a panel of four human cancer cell lines. Though the compounds showed varying degrees of cytotoxicity in the test
Synthesis and anti-inflammatory activity of fluorinated propanedione derivatives
More, Arpita H.,Ramaa
experimental part, p. 364 - 367 (2010/11/03)
A new series of five 1-(2′,4′-difluorophenyl)-3-(substituted phenyl)-1,3 propanediols from 2′,4′-difluorinated chalcones have been synthesized. All the compounds (20 mg/kg po) possess anti-inflammatory activity, as reflected by their ability to provide protection (70.00 - 93.00%) against carrageenan induced edema in rat paw. Standard indomethacin provided 79.00% protection at the same dose. The safety of these substituted propanediones are reflected by toxicity studies.
