122453-97-8

Upstream product

• 24393-52-0 ethyl (E)-3-(4-chlorophenyl)prop-2-enoate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 

Downstream Products

• 131924-84-0 1-Benzyl-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131924-88-4 4-(4-Chloro-phenyl)-1-(2,4-dichloro-benzyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131924-86-2 1-(4-Chloro-benzyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131924-87-3 1-(2-Chloro-benzyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 122453-98-9 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid 
• 131924-74-8 4-(4-chlorophenyl)-1-(2,4-dichlorobenzyl)-N-hydroxy-1H-pyrrol-3-hydroxamate 
• 131924-63-5 4-(4-Chloro-phenyl)-1-(2,4-dichloro-benzyl)-1H-pyrrole-3-carboxylic acid 
• 131924-62-4 1-(2-Chloro-benzyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid 
• 131924-61-3 1-(4-Chloro-benzyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid 
• 131924-60-2 4-(4-Chloro-phenyl)-1-(4-fluoro-benzyl)-1H-pyrrole-3-carboxylic acid 
• 131924-59-9 1-Benzyl-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid 
• 191667-82-0 1-allyl-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide 
• 191667-81-9 4-(4-chloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide 
• 191667-80-8 4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide 

Relevant academic research and scientific papers

N-(1-naphthylmethyl)-N-(1-alkyl-4-aryl-1H-pyrrol-3-yl methyl)methylamines related to naftifine. Synthesis and antifungal activity

Various pyrrole analogues of the antifungal drug naftifine were prepared starting from cinnamates via the tosylmethylisocyanide (TosMIC) reaction. After alkylation and hydrolysis, the intermediate arylpyrrole esters afforded 1-alkyl-4-aryl-1H-pyrrole-3-carboxylic acids, which were condensed with N-(1-naphthylmethyl)methylamine in the presence of EDCI and triethylamine. The related amides were then reduced with lithium aluminum hydride to the required N-(1-naphthylmethyl)-N-(1-alkyl-4-aryl-1H-pyrrol-3-ylmethyl)methylamines. The new compounds were evaluated for antifungal activity in comparison with naftifine and other imidazole drugs used in the clinic. Derivative 7c was active against Candida parapsilosis and compound 51 against Candida albicans. Weak activity against dermatophytes was shown by a number of derivatives. Moreover, compounds 4g, 4j, 4k and 4p were found active against Staphylococcus aureus with potencies comparable to that of streptomycin.

Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof

This invention is directed to certain novel insecticidal, acaricidal and nematicidal arylpyrrole agents and a method for controlling insects, acarids and nematodes therewith. The invention also is directed to a method for protecting growing plants from insect, acarid and nematode attack by applying to said plants or the soil in which they are growing, an insecticidally, acaricidally or nematicidally effective amount of a novel arylpyrrole compound. The present invention further is directed to a method for the preparation of the arylpyrrole compounds.

Method of controlling phytopathogenic fungi

This invention is directed to a method for the control of phytopathogenic fungi by contacting the same with a cyano- or nitroarylpyrrole compound, or by applying said pyrrole compound to the foliage of a plant susceptible to disease caused by said pathogens.

Method of and bait compositions for controlling mollusks

This invention relates to methods of controlling mollusks with arylpyrrole compounds and to bait compositions containing a molluscicidally effective amount of an arylpyrrole compound.