1224635-36-2

Upstream product

• 1224635-24-8 2-({2-[(4-methoxyphenyl)ethynyl]phenyl}ethynyl)aniline 
• 88207-45-8 2-(2'-bromophenyl)-1H-indole 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-63-0 phenylhydrazine 
• 948-65-2 2-phenyl-indole 

Relevant academic research and scientific papers

Multi-substituted 6-aryl benzo [a] carbazole, derivatives thereof, synthesizing method of multi-substituted 6-aryl benzo [a] carbazole

The invention relates to a multi-substituted 6-aryl benzo [a] carbazole, derivatives thereof, a synthesizing method of the multi-substituted 6-aryl benzo [a] carbazole. According to the synthesizing method of the multi-substituted 6-aryl benzo [a] carbazole, for the first time under catalysis of iodine compounds and in an air atmosphere, 2-aryl indole compounds, aromatic alkyne compounds or aromatic ketone compounds are converted into the multi-substituted 6-aryl benzo [a] carbazole and the derivatives thereof to prepare products and by-products, which are stable in molecular structure and excellent in chemical properties; reaction materials are low in price and easy to acquire and save pretreatment; reaction is high in atom economy and simple in operation and can be promoted through low-price iodine compounds, thereby being low in environmental pollution and reaction costs; the entire reaction system is simple, mild in reaction conditions, few in reaction equipment, simple and safe and experimental operation and rich and wide in material resources.

Selective Synthesis of Benzo[a]Carbazoles and Indolo[2,1-a]-Isoquinolines via Rh(III)-Catalyzed C?H Functionalizations of 2-Arylindoles with Sulfoxonium Ylides

A highly chem- and regioselective synthesis of diversely substituted benzo[a]carbazoles and indolo[2,1-a]-isoquinolines through Rh(III)-catalyzed cascade reactions of 2-arylindoles with sulfoxonium ylides is presented. To be specific, treatment of 2-arylindoles, 2-arylindole-3-carbaldehydes, 2-arylindole-3-carbonitriles or 2-aryl-3-methylindoles with sulfoxonium ylides under the catalysis of Rh(III) led to the selective formation of 6-aryl/alkyl benzo[a]carbazoles, 5-acylbenzo[a]carbazoles, 6-amino-5-acylbenzo[a]carbazoles or 12-methylindolo[2,1-a]isoquinolines, respectively. Mechanistically, the formation of the title compounds involves a cascade process including metalation of the inert C(sp2)?H bond, migratory insertion of ylide into the carbon-metal bond via an in situ carbenoid formation, protodemetalation, and condensation. To our knowledge, this is the first example in which β-carbonyl sulfoxonium ylides were used as stable carbene precursors and bifunctional C2 synthons to afford benzo[a]carbazoles and indolo[2,1-a]isoquinolines. (Figure presented.).

Method for synthesizing benzo[a]carbazole compound

The invention discloses a method for synthesizing a benzo[a]carbazole compound. The synthesis method uses a 2-aryl indole compound and sulfur ylide as raw materials to synthesize the benzo[a]carbazolecompound by a Rh(III) catalyzed series reaction. The me

Copper-catalyzed synthesis of benzocarbazoles via α-C-arylation of ketones

A simple and efficient copper-catalyzed method for the synthesis of 11H-benzo[a]carbazoles has been developed. The protocol uses readily available substituted 2-(2-bromophenyl)-1H-indoles and ketones as starting materials and an inexpensive catalyst system. The corresponding 11H-benzo[a]carbazoles were obtained in moderate to excellent yields. The Royal Society of Chemistry 2012..

Direct synthesis of fused indoles by gold-catalyzed cascade cyclization of diynes

A direct, concise, and atom-economical synthetic method for the generation of fused indoles, using a gold-catalyzed cascade cyclization of diynes, has been developed. The reaction gave various fused indoles, such as aryl-annulated[a]carbazoles, dihydrobenzo[g]indoles, and azepino-or oxepinoindole derivatives in good to excellent yields, through an intramolecular cascade 5-endo-dig hydroamination followed by a 6-or 7-endo-dig cycloisomerization, without producing theoretical byproduct. Three of the resulting indoles exhibited potent antifungal activities against T. mentagrophytes and T. rubrum, demonstrating the practical application of the described cascade reaction for drug discovery.(Figure Presented)

Gold-catalyzed intramolecular alkyne cycloisomerization cascade: Direct synthesis of aryl-annulated[a]carbazoles from aniline-substituted diethynylarenes

Aniline-substituted diethynylarenes, which are readily synthesized through Sonogashira coupling reactions from commercially available 1,2-dihaloarenes, directly produce aryl- and heteroaryl-annulated [a]carbazoles by the gold-catalyzed intramolecular casc