1224704-62-4

Basic information

• Product Name: 1-[4-[4-[(5-fluoro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]piperazin-1-yl]ethanone
• CAS NO: 1224704-62-4
• Molecular Weight: 461.499
• Mol File: 1224704-62-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[4-[4-[(5-fluoro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]piperazin-1-yl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-[4-[(5-fluoro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]piperazin-1-yl]ethanone(1224704-62-4)
• EPA Substance Registry System: 1-[4-[4-[(5-fluoro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]piperazin-1-yl]ethanone(1224704-62-4)

Safety Data

• Hazardous Substances Data: 1224704-62-4(Hazardous Substances Data)

Upstream product

• 1021426-42-5 1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one 
• 1037255-02-9 3-(2-chloro-5-fluoropyrimidin-4-yl)imidazo[1,2-a]pyridine 

Relevant articles and documents

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

We disclose a novel series of insulin-like growth factor-1 receptor kinase inhibitors based on the 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridine scaffold. The influence on the inhibitory activity of substitution on the imidazopyridine and at the C5 position of the pyrimidine is discussed. In the course of this optimization, we discovered a potent and selective inhibitor with suitable pharmacokinetics for oral administration.