1224734-27-3

Basic information

• Product Name: 2-((2-p-tolylhydrazinyl)methylene)-1H-indene-1,3(2H)-dione
• Synonyms: 2-((2-p-tolylhydrazinyl)methylene)-1H-indene-1,3(2H)-dione
• CAS NO: 1224734-27-3
• Molecular Weight: 278.31
• Mol File: 1224734-27-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((2-p-tolylhydrazinyl)methylene)-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2-p-tolylhydrazinyl)methylene)-1H-indene-1,3(2H)-dione(1224734-27-3)
• EPA Substance Registry System: 2-((2-p-tolylhydrazinyl)methylene)-1H-indene-1,3(2H)-dione(1224734-27-3)

Safety Data

• Hazardous Substances Data: 1224734-27-3(Hazardous Substances Data)

Upstream product

• 28752-91-2 2-[(dimethylamino)methylene]-1H-indene-1,3(2H)-dione 
• 539-44-6 N-4-methylphenylhydrazine 

Relevant articles and documents

Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as β-amyloid aggregation inhibitors

Biological screening of (hetero)aromatic compounds allowed the identification of some novel inhibitors of Aβ1-40 aggregation, bearing indane and indole rings as common scaffolds. Molecular decoration of lead compounds led to inhibitors exhibiting a potency, measured by the Thioflavin T fluorimetric assay, ranging from high to low micromolar IC50. The 2-(p-isopropylphenyldiazenylmethylene)indolone derivative 6c resulted as the most potent aggregation inhibitor exhibiting an IC50 of 1.4?μM, with complete lack of fibril formation as confirmed by transmission electron microscopy. Structure-activity relationships suggested that binding to the Aβ peptide may be largely guided by π-stacking and hydrogen bond interactions.