1224738-80-0

Basic information

• Product Name: benzyl-(2-bromo-5-methoxyphenyl)-amine
• Synonyms: benzyl-(2-bromo-5-methoxyphenyl)-amine
• CAS NO: 1224738-80-0
• Molecular Weight: 292.175
• Mol File: 1224738-80-0.mol

Chemical Properties

• CAS DataBase Reference: benzyl-(2-bromo-5-methoxyphenyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl-(2-bromo-5-methoxyphenyl)-amine(1224738-80-0)
• EPA Substance Registry System: benzyl-(2-bromo-5-methoxyphenyl)-amine(1224738-80-0)

Safety Data

• Hazardous Substances Data: 1224738-80-0(Hazardous Substances Data)

Upstream product

• 59557-92-5 2-bromo-5-methoxyaniline 
• 100-39-0 benzyl bromide 

Downstream Products

• 1224738-12-8 (E)-methyl 3-(2-(benzylamino)-4-methoxyphenyl)acrylate 
• 1242077-80-0 C₂₀H₂₂BrNO₂ 
• 1242077-86-6 C₂₁H₂₄BrNO₂ 
• 1242077-83-3 C₂₅H₃₁BrN₂O₄ 

Relevant articles and documents

Pd-catalyzed arylation/aza-Michael addition cascade to C2-spiroindolines and azabicyclo[3.2.2]nonanones

A palladium-catalyzed arylation/aza-Michael addition cascade reaction of β-substituted cyclic enones and 2-haloanilines has been reported. Using 1 mol% Pd(PPh3)4as a catalyst, C2-spiroindolines are accessedviaan intermolecular vinylogous arylation of β-alkyl cyclic enones and 2-haloanilines followed by an intramolecular aza-Michael addition. The functional group tolerance of this transformation is examined by 18 examples in up to 93% yield. In the second part, we developed an α′-arylation/aza-Michael addition cascade strategy to construct azabicyclo[3.2.2]nonanones catalyzed by Pd(MeCN)2Cl2·PPh3. This study provides a quick route to complex and useful spiro- and bridged-heterocycles from readily available starting materials in good yields with high regioselectivity.

Rhodium-catalyzed domino conjugate addition-cyclization reactions for the synthesis of a variety of N- and O-heterocycles: Arylboroxines as effective carbon nucleophiles

Facile and efficient Rh(I)-catalyzed domino conjugate addition-cyclization reactions of olefins bearing two electrophilic sites and a pendant nucleophile with organoboroxines have been developed to afford a variety of N- and O-heterocycles, such as 3,4-dihydroquinolin-2(1H)-ones, 3,4-dihydrocoumarins, and pyrrolidin-2-ones, which constitute important motifs in biologically active natural and synthetic organic compounds.