1224847-60-2

Upstream product

• 1224846-59-6 (2S)-5-amino-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid 
• 173604-88-1 (5-phenyl-2-oxo-1,3-dioxol-4-en-4-yl)methyl p-nitrophenyl carbonate 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 1224847-65-7 ethyl 4,5-dihydroimidazo[1,5-a]quinoline-3-carboxylate 
• 1224847-67-9 4,5-dihydroimidazo[1,5-a]quinoline-3-carbaldehyde 
• 1224847-68-0 tert-butyl (3E)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyliden)-2-oxopiperidine-1-carboxylate 
• 1224847-69-1 tert-butyl 3-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)-2-oxopiperidine-1-carboxylate 
• 1224847-70-4 5-[(tert-butoxycarbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid 
• 1224847-71-5 (1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoate 
• 1224847-73-7 (2S)-5-[(tert-butoxycarbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid 

Relevant academic research and scientific papers

COMPOUND HAVING TAFIA INHIBITORY ACTIVITY

Provided are compounds having superior TAFIa inhibitory activity. Specifically, there are provided compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: wherein A is a benzene ring or a pyridine ring; X is the formula -(CH2)-, the formula -(CH2)2-, an oxygen atom, a nitrogen atom or a single bond; Y is the formula -(CH2)3-NH-R3, the formula -(CH2)4-NH-R3 or a 2-aminopyridyl group; R3 is a hydrogen atom, a C1-6 alkyl group, or the formula -CO2R4; R4 is a C1-6 alkyl group, the formula -CHR5OC(O)R6, or a substituent having the structure represented by the following formula Ia; R5 is a C1-6 alkyl group; R6 is a C1-6 alkyl group, a C3-8 cycloalkyl group, or a phenyl group; R7 is a C1-6 alkyl group or a phenyl group; a R1 is a hydrogen atom, a halogen atom, a C1-4 alkyl group substituted by 1-3 halogen atoms, a C1-10 alkyl group, a C1-8 alkoxy group, a C3-8 cycloalkyl group, a C3-8 cycloalkoxy group, a C4-14 cycloalkylalkyl group, or a phenyl group; R2 is CO2R8, or a tetrazolyl group; R8 is a hydrogen atom, a C1-10 alkyl group, or a substituent having the structure represented by the following formula Ib or Ic; m and n are each an integer of zero or one.