122488-76-0

Basic information

• Product Name: 3-formamidobenzyl bromide
• Synonyms: 3-formamidobenzyl bromide
• CAS NO: 122488-76-0
• Molecular Weight: 214.062
• Mol File: 122488-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-formamidobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-formamidobenzyl bromide(122488-76-0)
• EPA Substance Registry System: 3-formamidobenzyl bromide(122488-76-0)

Safety Data

• Hazardous Substances Data: 122488-76-0(Hazardous Substances Data)

Upstream product

• 1877-77-6 3-aminobenzenemethanol 
• 122488-77-1 3-formamidobenzyl alcohol 

Downstream Products

• 123811-35-8 6-(dimethylamino)-9-(3-formamidobenzyl)-9H-purine 
• 123811-54-1 6-chloro-7-(formamidobenzyl)-7H-purine 
• 123811-53-0 6-chloro-9-(3-formamidobenzyl)-9H-purine 
• 136484-82-7 N-[3-(6-Benzylsulfanyl-purin-9-ylmethyl)-phenyl]-formamide 
• 136484-81-6 6-methylthio-9-(3-formamidobenzyl)-9H-purine 
• 136484-89-4 6-methylthio-7-(3-formamidobenzyl)-7H-purine 

Relevant articles and documents

Benzodiazepine Receptor Binding Activity of 8-Substituted-9-(3-substituted-benzyl)-6-(dimethylamino)9H-purines

A series of 8-substituted analogues of 9-(3-aminobenzyl)-6-(dimethylamino)-9H-purine (8) were synthesized and tested for their ability to bind to the benzodiazepine receptor (BZR) in rat brain tissue.The most active compound was the 8-bromo-9-(3-formamidobenzyl) analogue 16 (IC50 = 0.011 μM), which was 1000-fold more active than the parent 9-benzyl-6-(dimethylamino)-9H-purine (1) and nearly as active as diazepam.Although substitution of a m-formamido group and an 8-bromo substituent on 1 imparted potent BZR binding activity, neither 16 nor 17 analogues exhibited significant anxiolytic activity on a modified Geller-Seifter conflict schedule.