123811-54-1

Basic information

• Product Name: 6-chloro-7-(formamidobenzyl)-7H-purine
• CAS NO: 123811-54-1
• Molecular Weight: 287.708
• Mol File: 123811-54-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-chloro-7-(formamidobenzyl)-7H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-7-(formamidobenzyl)-7H-purine(123811-54-1)
• EPA Substance Registry System: 6-chloro-7-(formamidobenzyl)-7H-purine(123811-54-1)

Safety Data

• Hazardous Substances Data: 123811-54-1(Hazardous Substances Data)

Upstream product

• 122488-77-1 3-formamidobenzyl alcohol 
• 1877-77-6 3-aminobenzenemethanol 
• 122488-76-0 3-formamidobenzyl bromide 
• 87-42-3 6-chloropurine 

Relevant articles and documents

Benzodiazepine Receptor Binding Activity of 8-Substituted-9-(3-substituted-benzyl)-6-(dimethylamino)9H-purines

A series of 8-substituted analogues of 9-(3-aminobenzyl)-6-(dimethylamino)-9H-purine (8) were synthesized and tested for their ability to bind to the benzodiazepine receptor (BZR) in rat brain tissue.The most active compound was the 8-bromo-9-(3-formamidobenzyl) analogue 16 (IC50 = 0.011 μM), which was 1000-fold more active than the parent 9-benzyl-6-(dimethylamino)-9H-purine (1) and nearly as active as diazepam.Although substitution of a m-formamido group and an 8-bromo substituent on 1 imparted potent BZR binding activity, neither 16 nor 17 analogues exhibited significant anxiolytic activity on a modified Geller-Seifter conflict schedule.