1224933-70-3

Basic information

• Product Name: 2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid
• Synonyms: 2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid
• CAS NO: 1224933-70-3
• Molecular Weight: 234.175
• Mol File: 1224933-70-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid(1224933-70-3)
• EPA Substance Registry System: 2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid(1224933-70-3)

Safety Data

• Hazardous Substances Data: 1224933-70-3(Hazardous Substances Data)

Upstream product

• 374-01-6 (S)-1,1,1-trifluoro-2-propanol 
• 445-29-4 o-fluoro-benzoic acid 

Downstream Products

• 1224933-71-4 [5-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindol-2-yl]-[2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone 
• 1224933-72-5 3-[5-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindole-2-carbonyl]-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)benzenesulfonyl chloride 

Relevant articles and documents

Radiosynthesis of [5-[11C]methanesulfonyl-2-((S)-2,2,2- trifluoro-1-methyl-ethoxy)-phenyl]-[5-(tetrahydro-pyran-4-yl)-1, 3-dihydro-isoindol-2-yl]-methanone ([11C]RO5013853), a novel PET tracer for the glycine transporter type i (GlyT1)

The glycine transporter type 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. We have recently discovered and developed [11C]RO5013853 as a novel positron emission tomography tracer for GlyT1 for which a reliable five-step synthetic route was established. The incorporation of the radioisotope was achieved in the final step through methylation of a sodium sulfinate precursor, itself easily accessible upon reduction of the corresponding sulfonyl-chloride analog. [11C] RO5013853 was prepared with high specific activity (>49 GBq/μmol) and high radiochemical purity (100%). A validation study of [11C]RO5013853 in animal imaging studies is in progress. Copyright