1224944-51-7

Basic information

• Product Name: Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate
• Synonyms: Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate
• CAS NO: 1224944-51-7
• Molecular Formula: C₈H₆ClN₃O₂
• Molecular Weight: 211.60514
• Mol File: 1224944-51-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.44±0.40(Predicted)
• CAS DataBase Reference: Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate(1224944-51-7)
• EPA Substance Registry System: Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate(1224944-51-7)

Safety Data

• Hazardous Substances Data: 1224944-51-7(Hazardous Substances Data)

Usage

General Description

Methyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate is a chemical compound with a molecular formula of C8H6ClN3O2. It belongs to the class of pyrimidine derivatives and is often used as an intermediate in the synthesis of pharmaceutical and agrochemical compounds. Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate has potential biological activity and can be utilized in drug discovery research. Its molecular structure consists of a pyrazole ring fused with a pyrimidine ring, with a chlorine atom and a methyl ester group attached. Methyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate possesses a wide range of applications in the pharmaceutical industry and is a key component in the production of various therapeutic drugs.

Upstream product

• 29274-22-4 pyrazolo[1,5-a]pyrimidine-5-ol 
• 1224944-43-7 sodium pyrazolo[1,5-a] pyrimidin-5-olate 
• 1224944-45-9 methyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1224944-44-8 3-iodopyrazolo[1,5-a]pyrimidin-5(4H)-one 
• 29274-22-4 4H,5H-pyrazolo[1,5-a]pyrimidine-5-one 
• 67-56-1 methanol 
• 1224944-46-0 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 1224944-47-1 5-chloropyrazolo[1,5-a]pyrimidine-3-carbonyl chloride 

Downstream Products

• 1224939-90-5 methyl 5-(3-fluorobenzylamino)pyrazolo[1,5-a]pyrimidine-3-carboxylate 

Relevant articles and documents

Compounds used as JAK inhibitor, and use of compounds

The invention provides compounds used as a JAK inhibitor, and a use of the compounds, and concretely provides compounds (represented by formula (I)) with JAK inhibition activity or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and a medicinal composition including the compounds. The invention also discloses a use of the compounds or the medicinal composition thereof in the preparation of medicines used for treating autoimmune diseases or proliferative diseases.

PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS

The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula Ia and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient. Ia