1225-03-2

Basic information

• Product Name: (9β)-3-Hydroxyestra-1,3,5(10)-trien-17-one
• Synonyms: (9β)-3-Hydroxyestra-1,3,5(10)-trien-17-one;9β-Estrone
• CAS NO: 1225-03-2
• Molecular Formula: C₁₈H₂₂O₂
• Molecular Weight: 270.36608
• Mol File: 1225-03-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (9β)-3-Hydroxyestra-1,3,5(10)-trien-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: (9β)-3-Hydroxyestra-1,3,5(10)-trien-17-one(1225-03-2)
• EPA Substance Registry System: (9β)-3-Hydroxyestra-1,3,5(10)-trien-17-one(1225-03-2)

Safety Data

• Hazardous Substances Data: 1225-03-2(Hazardous Substances Data)

Usage

General Description

(9β)-3-Hydroxyestra-1,3,5(10)-trien-17-one, also known as 9β-estrone, is a naturally occurring steroid hormone and a derivative of estrogen. This chemical is an important hormone in the human body, involved in the regulation of the menstrual cycle, fertility, and the development of secondary sexual characteristics in females. It is also involved in the maintenance of bone density and the regulation of cholesterol levels. In addition, 9β-estrone has been found to have potential applications in hormone replacement therapy and the treatment of certain hormone-related conditions. However, it is important to note that excessive levels of this hormone can contribute to the development of certain types of cancer, such as breast and endometrial cancer.

Upstream product

• 53-16-7 Estrone 
• 98-80-6 phenylboronic acid 
• 50394-95-1 3-hydroxyestra-1,3,5⁽¹⁰⁾-trienyl toluene-p-sulfonate 
• 5173-47-7 17,17-ethylenedioxyestra-1,3,5⁽¹⁰⁾,9⁽¹¹⁾tetraen-3-ol 

Downstream Products

• 53-16-7 Estrone 
• 21231-98-1 3-(2-tetrahydropyranyloxy)-1,3,5(10)estratrien-17β-ol 
• 901-93-9 oestrone acetate 
• 1091-94-7 O-methyl-estrone 
• 690996-26-0 3-benzyloxy-estra-1,3,5(10),15-tetraen-17β-ol 
• 690996-25-9 17-acetyloxy-3-benzyloxy-estra-1,3,5⁽¹⁰⁾,15-tetraene 
• 690996-24-8 17-acetyl-3-benzyl estetrol 
• 690996-23-7 17-acetyl estetrol 
• 30653-26-0 estetrol 
• 858-98-0 3-benzyloxy-estra-1,3,5⁽¹⁰⁾-trien-17-one 

Relevant articles and documents

Structure-activity relationships of 9β-estrogens

The 9β isomers of estradiol-17β, estradiol-17α, estrone and 17-ethinylestradiol-17β were synthesized and compared with their 9α-counterparts in the rat uterine cytosol estrogen receptor, uterotropic, and gonadotropin release inhibition assays. Except for 17-ethinyl-9β-estradiol-17β which was as active as its 9α isomer in the uterotropic assay, none of the 9β estrogens exhibited any biological activity which was equal to or greater than their 9α counterparts. For examples, 9β-estradiol-17β was 1/10 as active as estradiol-17β, and 9β-estrone was 1/4 as active as estrone in the uterotropic assay.

Solvent- and Wavelength-Dependent Photolysis of Estrone

The direct photolysis of estrone in solvents ranging from water to cyclohexane is reported. The photodegradation is dominated by lumiestrone, an epimer of estrone resulting from the inversion of the methyl group at carbon 13, regardless of solvent and pho

Pd-catalyzed Suzuki–Miyaura couplings and evaluation of 13α-estrone derivatives as potential anticancer agents

13α-Estrones are of great value owing to their potent multiple bioactivity, including anticancer activity. 3-OH or 3-OBn derivatives of 2- or 4-[(subst.) phenyl]-13α-estrone as potential antiproliferative agents have been synthesized via facile, microwave