122503-20-2Relevant academic research and scientific papers
Facile solid-phase organic synthesis of 5-vinyl-substituted 1,2,4-oxadiazoles from polymer-bound α-selenopropionic acid
Hu, Qiao-Sheng,Sheng, Shou-Ri,Liu, Xiao-Ling,Hu, Fang,Cai, Ming-Zhong
experimental part, p. 768 - 771 (2009/12/01)
Cyclocondensation of polystyrene-supported α-selenopropionic acid with amidoximes in the presence of l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) followed by oxidative deselenation efficiently afforded 5-vinyl 1,2,4-oxadiazoles in good yield and purity with a facile work-up procedure.
A Simplified Procedure for Preparing 3,5-Disubstituted-1,2,4-Oxadiazoles by Reaction of Amidoximes with Acyl Chlorides in Pyridine Solution
Chiou, Shishue,Shine, Henry J.
, p. 125 - 128 (2007/10/02)
3-R-5-R'-1,2,4-Oxadiazoles are prepared in fair to good yield by short-time, one-pot reaction of an amidoxime, RC(NH2)NOH, with an acyl chloride, R'COCl, in pyridine solution.Precipitation of the oxadiazole occurs on diluting the pyridine reaction solutio
