1225049-99-9Relevant academic research and scientific papers
Caged mitochondrial uncouplers that are released in response to hydrogen peroxide
Quin, Caroline,Robertson, Linsey,McQuaker, Stephen J.,Price, Nicholas C.,Brand, Martin D.,Hartley, Richard C.
, p. 2384 - 2389 (2010)
Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (±0.8) M-1 s-1 and 64.8 (±0.6) M-1 s-1, respectively. The trigger mechanism involves conversion of an arylboronate into a phenol followed by fragmentation. Hydrogen peroxide-activated uncouplers may be useful for studying the biological process of ageing.
