1225289-63-3Relevant academic research and scientific papers
Practical Synthesis of α-Trifluoromethylated Pyridines Based on Regioselective Cobalt-Catalyzed [2+2+2] Cycloaddition using Trifluoromethylated Diynes with Nitriles
Kumon, Tatsuya,Yamada, Shigeyuki,Agou, Tomohiro,Fukumoto, Hiroki,Kubota, Toshio,Hammond, Gerald B.,Konno, Tsutomu
, p. 1912 - 1922 (2021/02/16)
Regioselective cobalt-catalyzed [2+2+2] cycloaddition using fluorine-containing diynes with nitriles was described. Cycloaddition of fluorinated diynes with nitriles under the influence of CoCl2(phen), zinc bromide, and zinc dust in dichloroethane at 80 °C for 3 h took place smoothly, exclusively affording the corresponding α-fluoroalkylated pyridines in excellent yields. In addition, dinitriles as substrate were also found to be suitable for this reaction, giving the corresponding fluoroalkylated bipyridine derivatives in excellent yields. (Figure presented.).
Rhodium-catalyzed [2+2+2] cycloaddition of various fluorine-containing alkynes - Novel synthesis of multi-substituted fluoroalkylated aromatic compounds
Konno, Tsutomu,Moriyasu, Kazuki,Kinugawa, Ryoko,Ishihara, Takashi
supporting information; experimental part, p. 1718 - 1724 (2010/07/04)
Treatment of various fluorinated internal alkynes with 10 mol% of RhCl 3·H2O and 30 mol% of i-Pr2NEt in toluene at the reflux temperature for 18 h gave the corresponding trimerization products as an isomeric mixture in hig
