1225322-64-4Relevant academic research and scientific papers
Direct C?H Trifluoromethylation of Quinoxalin-2(1H)-ones under Transition-Metal-Free Conditions
Wang, Liping,Zhang, Yuecheng,Li, Fanfan,Hao, Xinyu,Zhang, Hong-Yu,Zhao, Jiquan
, p. 3969 - 3977 (2018/09/14)
Disclosed herein is a direct C?H trifluoromethylation of quinoxalin-2(1H)-ones with sodium trifluoromethanesulfinate. This protocol affords a series of 3-trifluoromethylquinoxalin-2(1H)-one derivatives in moderate to excellent yields under transition-metal-free conditions. The present methodology features utilization of the inexpensive trifluoromethyl source without transition-metal-catalysts, mild reaction conditions and high functional group tolerance, which promises a convenient and efficient access to pharmaceutically interesting quinoxalinones. (Figure presented.).
3-trifluoromethyl quinoxalinone compound preparation method
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Paragraph 0050-0051, (2019/01/08)
The invention discloses a 3-trifluoromethyl quinoxalinone compound preparation method which comprises the following steps of in an inert gas atmosphere, adding a quinoxalinone compound, sodium trifluoromethanesulfinate and an oxidant in a solvent, performing reaction for 6-18 h at the temperature of 0-75 DEG C, and performing column chromatography separation and purification to obtain 3-trifluoromethyl substituted quinoxalinone compound. The 3-trifluoromethyl quinoxalinone compound preparation method provided by the invention is low in reagent cost, mild in reaction condition and simple in aftertreatment and is suitable for industrial production.
