1225327-16-1

Basic information

• Product Name: 5-(2-(phenylsulfonyl)ethyl)-1H-indole
• Synonyms: 5-(2-(phenylsulfonyl)ethyl)-1H-indole
• CAS NO: 1225327-16-1
• Molecular Weight: 285.367
• Mol File: 1225327-16-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 550.8±42.0 °C(Predicted)
• Density: 1.292±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-(2-(phenylsulfonyl)ethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-(phenylsulfonyl)ethyl)-1H-indole(1225327-16-1)
• EPA Substance Registry System: 5-(2-(phenylsulfonyl)ethyl)-1H-indole(1225327-16-1)

Safety Data

• Hazardous Substances Data: 1225327-16-1(Hazardous Substances Data)

Usage

Uses

Des-dimethylpyrrolidine Eletriptan is an impurity of the drug Eletriptan (E505000). Eletriptan is a serotonin 5-HTIB/ID receptor agonist and an antimigraine.

Upstream product

• 351186-42-0 N‐morpholinobenzenesulfonamide 
• 591-50-4 iodobenzene 
• 5535-48-8 PVS 
• 10075-50-0 5-bromo-1H-indole 
• 938-09-0 2-chloroethyl phenyl sulfone 
• 1268491-38-8 N-acetyl-5-(2-(phenylsulfonyl)ethyl)-1H-indole 
• 1268491-36-6 N-(4-(2-(phenylsulfonyl)ethyl)phenyl)acetamide 
• 312949-12-5 5-[(2-phenylsulfonyl)ethenyl]-1H-indole 
• 103-84-4 Acetanilid 

Downstream Products

• 143322-58-1 eletriptan 
• 1225327-17-2 (R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate 
• 1027171-27-2 (R)-(1-methylpyrrolidin-2-yl)(5-(2-(phenylsulfonyl)ethyl)-1H-indol-3-yl)methanone 
• 68742-28-9 5-ethyl-1H-indole 
• 1421592-40-6 C₁₇H₁₅NO₃S 
• 1421592-42-8 C₂₀H₁₆N₂O₄S₂ 

Relevant articles and documents

Magnesium catalyzed dephenylsulfonylation: Synthesis of 5-ethyl-1H-indole

A novel magnesium metal catalyzed synthesis of 5-ethyl-1H-indole from 5-[2-(phenyl sulfonyl)ethyl]-1H-indole by dephenylsulfonylation mechanism providing an alternative and attractive approach to 5-ethyl-1H-indole with high yields. This approach is for both the protected and unprotected indoles.

One-pot three-component sulfone synthesis exploiting palladium-catalysed aryl halide aminosulfonylation

A palladium-catalysed aminosulfonylation process is used as the key-step in a one-pot, three-component sulfone synthesis. The process combines aryl-, heteroaryl- and alkenyl iodides with a sulfonyl unit and an electrophilic coupling fragment. The sulfonyl unit is delivered in the form of an aminosulfonamide, which then serves as a masked sulfinate. The sulfinate is combined, in situ, with an electrophilic coupling partner, such as a benzylic, allylic or alkyl halide, an electron-poor arene, or a cyclic epoxide, to provide the corresponding sulfone products in good to excellent yields. The mild reaction conditions and use of commercially available reaction components allows the easy preparation of a broad range of sulfones featuring a variety of functional groups. The process obviates the need to employ thiol starting materials, and oxidative operations.

A NOVEL PROCESS FOR THE PREPARATION OF ELETRIPTAN

The present invention relates to a novel process for the preparation of (R)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole and its intermediates thereof.