351186-42-0

Basic information

• Product Name: N‐morpholinobenzenesulfonamide
• Synonyms: N‐morpholinobenzenesulfonamide
• CAS NO: 351186-42-0
• Molecular Weight: 242.299
• Mol File: 351186-42-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: N‐morpholinobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N‐morpholinobenzenesulfonamide(351186-42-0)
• EPA Substance Registry System: N‐morpholinobenzenesulfonamide(351186-42-0)

Safety Data

• Hazardous Substances Data: 351186-42-0(Hazardous Substances Data)

Upstream product

• 4319-49-7 1-aminomorpholine 
• 98-09-9 benzenesulfonyl chloride 
• 2553-19-7 diethoxydiphenylsilane 
• 780-69-8 triethoxyphenylsilane 
• 16978-76-0 1-phenyl-2-(piperidin-1-yl)diazene 
• 13056-98-9 3,3-diethyl-1-phenyltriaz-1-ene 
• 62-53-3 aniline 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 1483-72-3 diphenyliodonium chloride 
• 66003-76-7 Diphenyliodonium triflate 
• 936326-60-2 phenyl(2,4,6-trimethoxyphenyl)iodonium 4-methylbenzenesulfonate 

Downstream Products

• 3112-88-7 Benzyl phenyl sulfone 
• 1225327-16-1 5-(2-(phenylsulfonyl)ethyl)-1H-indole 

Relevant articles and documents

Structure–activity relationships (SARs) of α- ketothioamides as inhibitors of phosphoglycerate dehydrogenase (PHGDH)

For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role of the serine synthetic pathway, and particularly of the phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the pathway, to sustain cancer progression. Yet, because of very weak potencies usually in cell-based settings, the inhibitors reported so far failed to lay ground on the potential of this approach. In this paper, we report a structure–activity relationship study of a series of α-ketothioamides that we have recently identified. Interestingly, this study led to a deeper understanding of the structure–activity relationship (SAR) in this series and to the identification of new PHGDH inhibitors. The activity of the more potent compounds was confirmed by cellular thermal shift assays and in cell-based experiments. We hope that this research will eventually provide a new entry point, based on this promising chemical scaffold, for the development of therapeutic agents targeting PHGDH.

The Design of an In-Ex Tube for Gas Related Organic Reactions

Here, an interesting in-ex tube was designed for gas-related organic reactions. By using this specially designed reaction tube, several gas-reliant organic reactions are applicable, including CO, SO2, and H2. Moderate to good yields of the desired products were produced easily.

Catalytic conversion of aryl triazenes into aryl sulfonamides using sulfur dioxide as the sulfonyl source

Various sulfonamides have been synthesized from triazenes and sulfur dioxide. In the presence of just a catalytic amount of BF3· OEt2, a series of 1-aryl-triazenes were converted into sulfonyl hydrazines in good to excellent yields. When using CuCl2 as the catalyst, the corresponding sulfonamides can be produced from the 1-aryl triazenes in good yields. This journal is the Partner Organisations 2014.