1225335-95-4Relevant academic research and scientific papers
A concise route to dihydrobenzo[b]furans: Formal total synthesis of (+)-lithospermic acid
Fischer, Joshua,Savage, G. Paul,Coster, Mark J.
supporting information; experimental part, p. 3376 - 3379 (2011/09/12)
A sequence of Sonogashira coupling, Pd(II)-catalyzed carbonylative annulation, and benzofuran reduction (Mg, MeOH, NH4Cl) provides a convergent and modular synthetic route to trans-2-aryl-2,3-dihydrobenzo[b]furan- 3-carboxylates, which are a structural feature of numerous biologically active natural products. This versatile strategy was applied to the formal total synthesis of the anti-HIV natural product (+)-lithospermic acid.
Copper-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o -alkynylphenols and anilines
Swamy, Nalivela Kumara,Yazici, Arife,Pyne, Stephen G.
supporting information; experimental part, p. 3412 - 3419 (2010/07/02)
The CuX (X = I, Br, Cl, CN)-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o-alkynylphenol and -aniline derivatives give rise to 3-halo- and 3-cyanofuro[3,2-b]pyrroles, 3-iodo-, 3-bromo-, and 3-cyanobenzofurans, and 3-cyanoindoles, respectively.
