1225377-65-0

Basic information

• Product Name: 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate
• Synonyms: 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate
• CAS NO: 1225377-65-0
• Molecular Weight: 319.401
• Mol File: 1225377-65-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate(1225377-65-0)
• EPA Substance Registry System: 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate(1225377-65-0)

Safety Data

• Hazardous Substances Data: 1225377-65-0(Hazardous Substances Data)

Upstream product

• 101693-93-0 (5R)-5-methyl-2-(phenylthio)cyclohexan-1-one 
• 308358-04-5 (6R)-2,2,6-trimethyl-1-oxaspiro[2.5]octan-4-one 
• 89-82-7 pulegone 
• 1225377-92-3 3-((4R)-4-methyl-2-oxo-1-(phenylthio)cyclohexyl)propyl acetate 
• 1225377-61-6 3-((1R,2S,4R)-2-(cyanomethyl)-4-methyl-6-oxocyclohexyl)propyl acetate 
• 1225377-59-2 (R)-3-(4-methyl-6-oxocyclohex-1-en-1-yl)propyl acetate 

Downstream Products

• 1225377-69-4 2-((1S,2R,3R,5R)-3-ethynyl-2-(3-hydroxypropyl)-3-(benzylamino)-5-methylcyclohexyl)acetonitrile 
• 1225377-96-7 2-((1S,2R,3R,5R)-3-ethynyl-2-(3-hydroxypropyl)-3-((4-methoxybenzyl)amino)-5-methylcyclohexyl)acetonitrile 
• 1438285-83-6 C₄₄H₅₈N₄O₂Si 
• 1438285-84-7 C₄₄H₅₈N₄O₂Si 
• 1225377-71-8 2-((4aR,5R,7S,8aS)-1-benzyl-8a-ethynyl-7-methyldecahydroquinolin-5-yl)acetonitrile 
• 1438285-85-8 C₄₄H₅₈N₄OSi 
• 1438285-86-9 C₄₄H₅₈N₄OSi 
• 1225377-97-8 2-((4aR,5R,7S,8aS)-8a-ethynyl-1-(4-methoxybenzyl)-7-methyldecahydroquinolin-5-yl)acetonitrile 
• 1225377-74-1 (4aR,5S,10bR,12R)-1-benzyl-12-methyl-9-(trimethylsilyl)-8-((trimethylsilyl)ethynyl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline 
• 1225377-76-3 (4aR,5S,10bR,12R)-1-benzyl-12-methyl-9-((trimethylsilyl)ethynyl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline 
• 1438285-38-1 (4aR,5S,10bR,12R)-1-benzyl-9-(tert-butyldimethylsilyl)-8-((tertbutyldimethylsilyl)ethynyl)-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline 
• 1438285-39-2 (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-((triisopropylsilyl)-ethynyl)-9-(trimethylsilyl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline 
• 1438285-40-5 C₂₉H₃₇N₃SSi 
• 1438285-42-7 C₃₀H₃₈N₂SSi 

Relevant articles and documents

Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2

The first biological target for the natural product complanadine A has been determined. The pseudosymmetric alkaloid functions as a selective agonist for the Mas-related G protein-coupled receptor X2 (MrgprX2), a G protein-coupled receptor that is highly expressed in neurons. Given the potential of MrgprX2 to function as a modulator of pain, complanadine A represents a new chemical probe to selectively interrogate the physiological function of MrgprX2 as well as a potential lead for the development of antihyperalgesics for the treatment of persistent pain. While complanadine A possess agonistic activity the related natural product lycodine, representing half of complanadine A, lacks activity providing a cursory description of the structural requirements for agonistic activity.