1225377-67-2Relevant articles and documents
Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2
Johnson, Trevor,Siegel, Dionicio
, p. 3512 - 3515 (2014/07/22)
The first biological target for the natural product complanadine A has been determined. The pseudosymmetric alkaloid functions as a selective agonist for the Mas-related G protein-coupled receptor X2 (MrgprX2), a G protein-coupled receptor that is highly expressed in neurons. Given the potential of MrgprX2 to function as a modulator of pain, complanadine A represents a new chemical probe to selectively interrogate the physiological function of MrgprX2 as well as a potential lead for the development of antihyperalgesics for the treatment of persistent pain. While complanadine A possess agonistic activity the related natural product lycodine, representing half of complanadine A, lacks activity providing a cursory description of the structural requirements for agonistic activity.
Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion
Yuan, Changxia,Chang, Chih-Tsung,Axelrod, Abram,Siegel, Dionicio
supporting information; experimental part, p. 5924 - 5925 (2010/07/05)
A total synthesis of the Lycopodium alkaloid (+)-complanadine A is described. Complanadine A has been shown to induce the secretion of neurotrophic factors from 1321N1 cells, promoting the differentiation of PC-12 cells. The use of a simplifying metal mediated [2+2+2] + [2+2+2] sequence using a silyl-substituted diyne and 2 equiv of the corresponding alkyne-nitrile has provided rapid access to the natural product.