1225463-01-3

Upstream product

• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 593-56-6 N-methoxylamine hydrochloride 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 

Downstream Products

• 1225462-94-1 7-(trifluoromethyl)-3,4-diphenylisoquinolin-1(2H)-one 
• 1280681-78-8 C₃₂H₂₂F₃NO₃ 
• 1609939-36-7 2-methoxy-3-phenyl-7-(trifluoromethyl)isoquinolin-1(2H)-one 
• 1609939-65-2 N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide 
• 1417712-54-9 (R)-2-(1-cyclohexylidene-4-methoxybutan-2-yl)-N-methoxy-5-(trifluoromethyl)benzamide 
• 1581719-94-9 N-methoxy-5-trifluoromethyl-2-((triisopropylsilyl)ethynyl)benzamide 
• 1380546-68-8 2-(3-butylhept-2-enyl)-N-methoxy-5-(trifluoromethyl)benzamide 
• 1268451-37-1 (E)-2-styryl-5-(trifluoromethyl)benzamide 

Relevant academic research and scientific papers

Indole- and Pyrrole-BX: Bench-Stable Hypervalent Iodine Reagents for Heterocycle Umpolung

The one-step synthesis of the bench-stable hypervalent iodine reagents IndoleBX and PyrroleBX using mild Lewis acid catalyzed conditions is reported. The new reagents are stable up to 150 °C and were applied in the C?H arylation of unactivated arenes using either rhodium or ruthenium catalysts. A broad range of heterocyclic systems of high interest for synthetic and medicinal chemistry was accessed in high yields. The developed C?H functionalization could not be achieved using reported reagents or methods, highlighting the unique reactivity of Indole- and Pyrrole-BX.

Mild rhodium(III)-catalyzed C-H allylation with 4-vinyl-1,3-dioxolan-2-ones: Direct and stereoselective synthesis of (E)-allylic alcohols

A rhodium(III)-catalyzed C-H direct allylation reaction with 4-vinyl-1,3-dioxolan-2-ones has been developed. The reaction provides a facile and stereoselective access to substituted-(E)-allylic alcohols under mild and redox-neutral reaction conditions. Olefinic C-H activation is applicable, giving multifunctionalized skipped dienes in good yields. Minimal double-bond migration was observed.

Rh(III)-catalyzed Directed C-H Olefination using an oxidizing directing group: Mild, efficient, and versatile

An efficient Rh(III)-catalyzed oxidative olefination by directed C-H bond activation of N-methoxybenzamides is reported. In this mild, practical, selective, and high-yielding process, the N-O bond acts as an internal oxidant. In addition, simply changing the substituent of the directing/oxidizing group results in the selective formation of valuable tetrahydroisoquinolinone products.

Rhodium(III)-catalyzed isoquinolone synthesis: The N-O bond as a handle for C-N bond formation and catalyst turnover

An external-oxidant-free process to access the isoquinolone motif via cross-coupling/cyclization of benzhydroxamic acid with alkynes is described. The reaction features a regioselective cleavage of a C-H bond on the benzhydroxamic acid coupling partner as well as a regioselective alkyne insertion. Mechanistic studies point out the important involvement of a N-O bond as a tool for C-N bond formation and catalyst turnover.