1609939-65-2

Upstream product

• 13735-81-4 1-styrenyloxytrimethylsilane 
• 1225463-01-3 methyl N-methoxy-3-(trifluoromethyl)benzamide 
• 20187-61-5 mesyloxyacetophenone 

Downstream Products

• 1609939-36-7 2-methoxy-3-phenyl-7-(trifluoromethyl)isoquinolin-1(2H)-one 

Relevant academic research and scientific papers

α-Arylation of Silyl Enol Ethers via Rhodium(III)-Catalyzed C-H Functionalization

Carbon-hydrogen (C-H) bond functionalization streamlines synthesis by increasing step-and atom-economies. This approach, catalyzed by Rh(III), is combined with the α-arylation of ketone-derived silyl enol ethers to achieve a direct cross-coupling event. T

α-MsO/TsO/Cl ketones as oxidized alkyne equivalents: Redox-neutral rhodium(III)-catalyzed C-H activation for the synthesis of N-heterocycles

α-Halo and pseudohalo ketones are used for the first time as C(sp3)-based electrophiles in transition-metal-catalyzed C-H activation and as oxidized alkyne equivalents in RhIII-catalyzed redox-neutral annulations to generate diverse N-heterocycles. This transformation is efficient and scalable. Due to the mild reaction conditions, a variety of functional groups could be tolerated. Who needs alkynes? α-Halo and pseudohalo ketones (as C(sp3)-based electrophiles) are utilized as oxidized alkyne equivalents in RhIII-catalyzed redox-neutral annulations to efficiently generate diverse N-heterocycles. Owing to the mild reaction conditions, a variety of functional groups are tolerated.