1225532-89-7

Usage

Uses

Used in Pharmaceutical Synthesis:
Diisopropyl 3,3-difluorocyclobutane-1,1-dicarboxylate is utilized as a key intermediate in the production of various pharmaceuticals. Its application is attributed to its ability to form stable and strong bonds with other molecules, which is crucial for the development of effective drug compounds.
Used in Agrochemical Production:
In the agrochemical industry, diisopropyl 3,3-difluorocyclobutane-1,1-dicarboxylate serves as a vital component in the synthesis of pesticides and other crop protection agents. Its use is justified by its capacity to enhance the stability and effectiveness of these products, thereby contributing to improved agricultural yields.
Used as a Reagent in Organic Synthesis Reactions:
Diisopropyl 3,3-difluorocyclobutane-1,1-dicarboxylate is employed as a reagent in various organic synthesis processes. Its application is driven by its reactivity and propensity to form robust bonds, which are essential for the successful synthesis of complex organic molecules.
Safety Considerations:
It is important to handle diisopropyl 3,3-difluorocyclobutane-1,1-dicarboxylate with caution due to its toxic nature if ingested. Additionally, it can cause skin and eye irritation upon contact, necessitating appropriate safety measures during its use in laboratories and industrial settings.

Upstream product

• 115118-68-8 3,3-dimethoxycyclobutane-1,1-dicarboxylic acid diisopropyl ester 
• 893724-10-2 dipropan-2-yl 3-oxocyclobutane-1,1-dicarboxylate 

Downstream Products

• 1225532-86-4 1-amino-3,3-difluorocyclobutane-1-carboxylic acid 

Relevant academic research and scientific papers

Multigram Synthesis of Advanced 6,6-Difluorospiro[3.3]heptane-Derived Building Blocks

A convenient methodology for constructing 6,6-difluorospiro[3.3]heptane scaffold – a conformationally restricted isoster of gem-difluorocycloalkanes – is developed. A large array of novel 2-mono- and 2,2-bifunctionalized difluorospiro[3.3]heptane building blocks was obtained through the convergent synthesis strategy using a common synthetic precursor – 1,1-bis(bromomethyl)-3,3-difluorocyclobutane. The target compounds and intermediates were prepared by short reaction sequences (6–10 steps) on a multigram scale (up to 0.47 kg).

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.