1225599-16-5Relevant articles and documents
INTERMEDIATES FOR THE PREPARATION OF REMIFENTANIL HYDROCHLORIDE
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Paragraph 0059-0068; 0072, (2020/05/14)
A new intermediate for synthesizing 1-substituted-4-[phenyl(propanoyl)amino]piperidine-4-carbonitrile derivatives is laid open. Specifically set out is a method for use of this intermediate in the preparation of remifentanil. The enclosed shorter process offers a greater yield of products with higher purity as compared to methods reported in the prior art.