542-76-7 Usage
Chemical Properties
3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor
Uses
Different sources of media describe the Uses of 542-76-7 differently. You can refer to the following data:
1. In pharmaceutical and polymer synthesis. Combines the reactivity of a nitrile and an alkyl halide. Because of the cyano group the chlorine atom is more reactive than in ordinary alkyl halides.
2. 3-Chloropropionitrile is used in pharmaceutical and polymer synthesis.
General Description
Colorless liquid with a characteristic acrid odor. Used in pharmaceutical and polymer synthesis.
Reactivity Profile
Toxic gas (hydrogen chloride) is released when the compound is heated above 266 F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat. [EPA, 1998].
Hazard
Toxic by ingestion, inhalation, and skin
contact. Combustible.
Health Hazard
Toxic effects are a result of systemic cyanide poisoning. (Non-Specific -- Cyanide) Few poisons are more rapidly lethal. Average oral lethal dose for hydrogen cyanide is approximately 60-90 mg (corresponds to 200 mg of potassium cyanide). Cause of death is lack of oxygen to the body's cells (especially the brain and heart) as a result of the chemical inhibiting cell enzymes.
Fire Hazard
Toxic gas (hydrogen chloride) is released when the compound is heated above 266F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat.
Potential Exposure
This material is used in pharmaceutical manufacture and in polymer synthesis.
Shipping
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
Incompatibilities
Contact with strong oxidizers may cause a fire and explosion hazard
Check Digit Verification of cas no
The CAS Registry Mumber 542-76-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 542-76:
(5*5)+(4*4)+(3*2)+(2*7)+(1*6)=67
67 % 10 = 7
So 542-76-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H4ClN/c4-2-1-3-5/h1-2H2
542-76-7Relevant articles and documents
METHOD OF CONVERTING ALCOHOL TO HALIDE
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Page/Page column 53; 132; 142; 143, (2017/01/02)
The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.
Efficient One-Step Transformation of Carboxylic Acids to Nitriles with the Carbon Chain Shortened by One Carbon Atom
Smushkevich, Y. I.,Smushkevich, V. Y.,Usorov, M. I.
, p. 1727 - 1736 (2007/10/03)
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AN EFFICIENT ONE-POT SYNTHESIS OF NITRILES FROM ACID CHLORIDES
Hulkenberg, A.,Troost, J.J.
, p. 1505 - 1508 (2007/10/02)
Treatment of aliphatic, aromatic as well as heterocyclic acid chlorides with sulfonamide in sulfolane at 120 deg C for 3 hours produces the corresponding nitriles in high yields.
