1225607-54-4

Basic information

• Product Name: 6-phenyl-1,3-benzoxazol-2(3H)-one
• Synonyms: 6-phenyl-1,3-benzoxazol-2(3H)-one
• CAS NO: 1225607-54-4
• Molecular Weight: 211.22
• Mol File: 1225607-54-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-phenyl-1,3-benzoxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenyl-1,3-benzoxazol-2(3H)-one(1225607-54-4)
• EPA Substance Registry System: 6-phenyl-1,3-benzoxazol-2(3H)-one(1225607-54-4)

Safety Data

• Hazardous Substances Data: 1225607-54-4(Hazardous Substances Data)

Upstream product

• 19932-84-4 6-chlorobenzo[d]oxazol-2(3H)-one 
• 100-58-3 phenylmagnesium bromide 
• 19932-85-5 6-bromobenzo[d]oxazol-2(3H)-one 
• 98-80-6 phenylboronic acid 
• 19213-72-0 ethyl 1-imidazolecarboxylate 
• 4363-03-5 2-amino 5-phenyl phenol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 18062-89-0 2-nitro 5-phenyl phenol 

Downstream Products

• 1396795-84-8 (2-oxo-6-phenyl-1,3-benzoxazol-3(2H)-yl)acetic acid 
• 1396795-85-9 C₂₂H₁₈N₂O₃ 
• 1396795-83-7 tert-butyl (2-oxo-6-phenyl-1,3-benzoxazol-3(2H)-yl)acetate 

Relevant articles and documents

General and efficient synthesis of benzoxazol-2(3H)-ones: Evolution of their anti-cancer and anti-mycobacterial activities

A novel class of benzo[d]oxazol-2(3H)-one derivatives has been synthesized and their in vitro cytotoxicity against human pancreatic adenocarcinoma and human non-small cell lung carcinoma cancer cell lines was evaluated. Many of these compounds were found to display excellent to moderate activity. Among them, 6b, 6l, 6n and 6x were identified as lead molecules. In particular, 6l and 6n were found to be potent against the pancreatic adenocarcinoma cell line whereas the 6x was found to be effective against the human non-small cell lung carcinoma cell line. Conversely, the compounds 6l-x were found to be ineffective against Mycobacterium tuberculosis. Of the various molecules, 6h showed promising anti-mycobacterial activity, with an IC50 value equal to that of ciprofloxacin.

BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.

Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands

Selective 18 kDa translocator protein (TSPO) ligands are expected to be therapeutic agents with a wide spectrum of action on psychiatric disorders and fewer side effects. We designed novel benzoxazolone derivatives and examined the structure-activity rela