18062-89-0

Usage

InChI:InChI=1/C12H9NO3/c14-12-8-10(6-7-11(12)13(15)16)9-4-2-1-3-5-9/h1-8,14H

Upstream product

• 92-93-3 1-phenyl-4-nitrobenzene 
• 75-52-5 nitromethane 
• 580-51-8 [1,1'-biphenyl]-3-ol 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 71-43-2 benzene 

Downstream Products

• 4363-03-5 2-amino 5-phenyl phenol 
• 1225607-54-4 6-phenyl-1,3-benzoxazol-2(3H)-one 
• 1396795-83-7 tert-butyl (2-oxo-6-phenyl-1,3-benzoxazol-3(2H)-yl)acetate 
• 1396795-84-8 (2-oxo-6-phenyl-1,3-benzoxazol-3(2H)-yl)acetic acid 
• 1396795-85-9 C₂₂H₁₈N₂O₃ 
• 13347-44-9 2-hydroxy-4-phenylacetanilide 

Relevant academic research and scientific papers

Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands

Selective 18 kDa translocator protein (TSPO) ligands are expected to be therapeutic agents with a wide spectrum of action on psychiatric disorders and fewer side effects. We designed novel benzoxazolone derivatives and examined the structure-activity rela

IL-8 RECEPTOR ANTAGONISTS

The present invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease states mediated by the chemokine Interleukin-8 (IL-8).

IL-8 RECEPTOR ANTAGONISTS

This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in treating chemokine mediated diseases wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (Ia) are represented by the structure: STR1 wherein interalia, X is oxygen or sulfur;Rb is NR 6 R. sub.7, alkcyl, aryl, arylC 1-4 alkyl, aryl C 2-4 alkenyl, heteroaryl, heteroarylC 1-4 alkyl, heteroarylC 2-4 alkenyl, heterocyclic or heterocyclic C 1-4 alkyl, or a heterocyclic C 2-4 alkenyl moiety, camphor, all of which may be optionally substituted; R 1 is independently selected from hydrogen; halogen; nitro; cyano; C 1-10 alkyl; halosubstituted C 1-10 alkyl; C 2-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR. sub.8 R 8)q S(O) t R 4 ; hydroxy; hydroxy substituted C 1-4 alkyl; aryl; aryl C 1-4 alkyl; aryl C 2-10 alkenyl; aryloxy; aryl C 1-4 alkyloxy; heteroaryl; heteroarylalkyl; heteroaryl C 2-10 alkenyl; heteroaryl C 1-4 alkyloxy; heterocyclic; heterocyclic C 1-4 alkyl; heterocyclicC 1-4 alkyloxy; heterocyclic C 2-10 alkenyl; q is 0 or an integer having a value of 1 to 10; n is an integer having a value of 1 to 3;m is an integer having a value of 1 to 3; Y is hydrogen; halogen; nitro; cyano; halosubstituted C 1-10 alkyl; C 1-10 alkyl; C 2-10 alkenyl C. sub.1-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR 8 R. sub.8)qS(O) t R 4, (CR 8 R 8)qOR 4 ; hydorxy; hydroxy substituted C. sub.1-4 alkyl; aryl; aryl C 1-4 alkyl; aryloxy; arylC. sub.1-4 alkyloxy; aryl C 2-10 alkenyl; heteroaryl; heteroarylalkyl; heteroaryl C 1-4 alkyloxy; heteroaryl C 2-10 alkenyl; heterocyclic, heterocyclic C 1-4 alkyl; heterocyclicC 2-10 alkenyl;or a pharmaceutically acceptable salt thereof.

REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. I. SUBSTITUTION OF HYDROGEN ATOM BY HYDROXY GROUP IN AROMATIC NITRO COMPOUNDS BY THE ACTION OF POTASSIUM HYDROXIDE AND OXYGEN

The reaction of nitrobenzene and 1-nitro- and 1,5- and 1,8-dinitronaphthalenes with potassium hydroxide and oxygen in liquid ammonia at -33 deg C gives nitrophenols and nitro- and dinitronaphthols respectively, corresponding to substitution of the hydrogen atom of the hydroxy group at the ortho and para positions to the nitro group. 4-Nitro-3-hydroxybiphenyl was obtained from 4-nitrobiphenyl under analogous conditions.The reaction of 1-nitronaphthalene with potassium hydroxide and oxygen at -70 deg C is characterized by exclusive ortho entry of the hydroxy group in relation to the nitro group.