1225709-69-2Relevant academic research and scientific papers
A Catalytic One-Pot Synthesis of Indolyl Cyclobutanones
Porcu, Stefania,Rodriguez, Carla Aira,Frongia, Angelo,Secci, Francesco
, p. 925 - 932 (2021)
A general strategy for the synthesis of indolyl cyclobutanones via a tandem Bronsted acid catalyzed 2-hydroxycyclobutanone activation-indole nucleophilic addition has been exploited. The procedure leads to a wide range of 2- and 3-functionalized indole derivatives in good to high yields with broad substrate scope.
Catalytic Tandem Friedel-Crafts Alkylation/C4-C3 Ring-Contraction Reaction: An Efficient Route for the Synthesis of Indolyl Cyclopropanecarbaldehydes and Ketones
Turnu, Francesca,Luridiana, Alberto,Cocco, Andrea,Porcu, Stefania,Frongia, Angelo,Sarais, Giorgia,Secci, Francesco
supporting information, p. 7329 - 7332 (2019/10/02)
A general strategy for the synthesis of indolyl cyclopropanecarbaldehydes and ketones via a Br?nsted acid-catalyzed indole nucleophilic addition/ring-contraction reaction sequence has been exploited. The procedure leads to a wide panel of cyclopropyl carbonyl compounds in generally high yields with a broad substrate scope.
Indole functionalization via photoredox gold catalysis
Kaldas, Sherif J.,Cannillo, Alexandre,McCallum, Terry,Barriault, Louis
, p. 2864 - 2866 (2015/06/16)
The use of photoredox catalyst [Au2(dppm)2]Cl2 to initiate free-radical cyclizations onto indoles is reported. Excitation of the dimeric Au(I) photocatalyst for the reduction of unactivated bromoalkanes and bromoarenes is used for the generation of carbon-centered radicals. Previous to this work, reduction processes leading to indole functionalization utilizing photoredox catalysts were limited to activated benzylic or α-carbonyl-positioned bromoalkanes. This method offers a mild and safe alternative to organostannanes and pyrophoric initiators for access to high energy radicals that were previously inaccessible through catalytic or stoichiometric means.
Suzuki-miyaura cross-coupling of potassium trifluoro(N -methylheteroaryl) borates with aryl and heteroaryl halides
Molander, Gary A.,Ryu, Daweon,Hosseini-Sarvari, Mona,Devulapally, Rammohan,Seapy, Dave G.
, p. 6648 - 6656 (2013/07/26)
The synthesis of potassium trifluoro(N-methylheteroaryl)borates and their use in cross-coupling reactions with various aryl and heteroaryl halides to construct N-methyl heteroaryl-substituted aromatic and heteroaromatic compounds are reported.
